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Evaluation of plasma tau and neurofilament light chain biomarkers in a 12-year clinical cohort of human prion diseases

Prion diseases are fatal neurodegenerative conditions with highly accurate CSF and imaging diagnostic tests, but major unmet needs for blood biomarkers. Using ultrasensitive immuno-assays, we measured tau and neurofilament light chain (NfL) protein concentrations in 709 plasma samples taken from 377...

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Detalles Bibliográficos
Autores principales:	Thompson, Andrew G. B., Anastasiadis, Prodromos, Druyeh, Ronald, Whitworth, Ines, Nayak, Annapurna, Nihat, Akin, Mok, Tze How, Rudge, Peter, Wadsworth, Jonathan D. F., Rohrer, Jonathan, Schott, Jonathan M., Heslegrave, Amanda, Zetterberg, Henrik, Collinge, John, Jackson, Graham S., Mead, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758487/ https://www.ncbi.nlm.nih.gov/pubmed/33674752 http://dx.doi.org/10.1038/s41380-021-01045-w

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