Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease

Genetic association studies for blood cell traits, which are key indicators of health and immune function, have identified several hundred associations and defined a complex polygenic architecture. Polygenic scores (PGSs) for blood cell traits have potential clinical utility in disease risk predicti...

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Detalles Bibliográficos
Autores principales: Xu, Yu, Vuckovic, Dragana, Ritchie, Scott C., Akbari, Parsa, Jiang, Tao, Grealey, Jason, Butterworth, Adam S., Ouwehand, Willem H., Roberts, David J., Di Angelantonio, Emanuele, Danesh, John, Soranzo, Nicole, Inouye, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758502/
https://www.ncbi.nlm.nih.gov/pubmed/35072137
http://dx.doi.org/10.1016/j.xgen.2021.100086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758502/
https://www.ncbi.nlm.nih.gov/pubmed/35072137
http://dx.doi.org/10.1016/j.xgen.2021.100086

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