A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor

Aromatic amines in nature are typically installed with Glu or Gln as the nitrogen donor. Here we report a pathway that features glycyl-tRNA as the nitrogen donor. During the biosynthesis of pyrroloiminoquinone-type natural products such as ammosamide, peptide-aminoacyl tRNA ligases (PEARLs) append a...

Descripción completa

Detalles Bibliográficos
Autores principales: Daniels, Page N., Lee, Hyunji, Splain, Rebecca A., Ting, Chi P., Zhu, Lingyang, Zhao, Xiling, Moore, Bradley S., van der Donk, Wilfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758506/
https://www.ncbi.nlm.nih.gov/pubmed/34725492
http://dx.doi.org/10.1038/s41557-021-00802-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758506/
https://www.ncbi.nlm.nih.gov/pubmed/34725492
http://dx.doi.org/10.1038/s41557-021-00802-2

Ejemplares similares