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Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metab...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758529/ https://www.ncbi.nlm.nih.gov/pubmed/34521729 http://dx.doi.org/10.1136/thoraxjnl-2021-217315 |
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author | Whalen, William Buyukozkan, Mustafa Moore, Bethany Moon, Jong-Seok Dela Cruz, Charles S Martinez, Fernando J Choi, Augustine M K Krumsiek, Jan Stout-Delgado, Heather Cho, Soo Jung |
author_facet | Whalen, William Buyukozkan, Mustafa Moore, Bethany Moon, Jong-Seok Dela Cruz, Charles S Martinez, Fernando J Choi, Augustine M K Krumsiek, Jan Stout-Delgado, Heather Cho, Soo Jung |
author_sort | Whalen, William |
collection | PubMed |
description | Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF. |
format | Online Article Text |
id | pubmed-8758529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-87585292022-01-26 Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis Whalen, William Buyukozkan, Mustafa Moore, Bethany Moon, Jong-Seok Dela Cruz, Charles S Martinez, Fernando J Choi, Augustine M K Krumsiek, Jan Stout-Delgado, Heather Cho, Soo Jung Thorax Brief Communication Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF. BMJ Publishing Group 2022-02 2021-09-14 /pmc/articles/PMC8758529/ /pubmed/34521729 http://dx.doi.org/10.1136/thoraxjnl-2021-217315 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Brief Communication Whalen, William Buyukozkan, Mustafa Moore, Bethany Moon, Jong-Seok Dela Cruz, Charles S Martinez, Fernando J Choi, Augustine M K Krumsiek, Jan Stout-Delgado, Heather Cho, Soo Jung Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis |
title | Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis |
title_full | Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis |
title_fullStr | Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis |
title_full_unstemmed | Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis |
title_short | Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis |
title_sort | association of circulating cell-free double-stranded dna and metabolic derangements in idiopathic pulmonary fibrosis |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758529/ https://www.ncbi.nlm.nih.gov/pubmed/34521729 http://dx.doi.org/10.1136/thoraxjnl-2021-217315 |
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