Cargando…

Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase

Retinoic acid-related orphan receptor alpha (RORA) suppression is associated with autism spectrum disorder (ASD) development, although the mechanism remains unclear. In this study, we aim to investigate the potential effect and mechanisms of RORA suppression on autism-like behavior (ALB) through mat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Hong, Niu, Yanbin, Jia, Guohua, Liang, Yujie, Chen, Baolin, Sun, Ruoyu, Wang, Min, Huang, Saijun, Zeng, Jiaying, Lu, Jianpin, Li, Ling, Guo, Xiaoling, Yao, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758718/ https://www.ncbi.nlm.nih.gov/pubmed/35027651 http://dx.doi.org/10.1038/s42003-022-03005-8

Ejemplares similares

Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring
por: Xiao, Li, et al.
Publicado: (2022)

Hematopoietic stem cell transplantation ameliorates maternal diabetes–mediated gastrointestinal symptoms and autism‐like behavior in mouse offspring
por: Zeng, Jiaying, et al.
Publicado: (2022)

Prenatal Progestin Exposure-Mediated Oxytocin Suppression Contributes to Social Deficits in Mouse Offspring
por: Huang, Saijun, et al.
Publicado: (2022)

RORA and Autism in The Isfahan Population: Is There An Epigenetic Relationship
por: Salehi, Mansoor, et al.
Publicado: (2017)

Maternal Diabetes-Induced Suppression of Oxytocin Receptor Contributes to Social Deficits in Offspring
por: Liu, Jianbo, et al.
Publicado: (2021)

Sex Hormones in Autism: Androgens and Estrogens Differentially and Reciprocally Regulate RORA, a Novel Candidate Gene for Autism
por: Sarachana, Tewarit, et al.
Publicado: (2011)

Rora Regulates Neutrophil Migration and Activation in Zebrafish
por: Hsu, Alan Y., et al.
Publicado: (2022)

A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137
por: Devanna, Paolo, et al.
Publicado: (2014)

Role of simvastatin and RORa activity in the macrophage apoptotic pathway
por: Çoban, Neslihan, et al.
Publicado: (2017)

Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder
por: Sarachana, Tewarit, et al.
Publicado: (2013)

Differential recruitment of coregulators to the RORA promoter adds another layer of complexity to gene (dys) regulation by sex hormones in autism
por: Sarachana, Tewarit, et al.
Publicado: (2013)

Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism
por: Hu, Valerie W, et al.
Publicado: (2015)

Mapping Rora expression in resting and activated CD4+ T cells
por: Haim-Vilmovsky, Liora, et al.
Publicado: (2021)

The suppressive functions of Rora in B lineage cell proliferation and BCR/ABL1-induced B-ALL pathogenesis
por: Li, Ning, et al.
Publicado: (2022)

Editorial: Contribution of the maternal microbiome to offspring health
por: Benítez-Páez, Alfonso
Publicado: (2023)

MicroRNA-transcription factor network analysis reveals miRNAs cooperatively suppress RORA in oral squamous cell carcinoma
por: Zheng, Xueqing, et al.
Publicado: (2018)

POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulating HIF1A signaling pathway
por: Xiao, Wenjing, et al.
Publicado: (2022)

Maternal elevated salt consumption and the development of autism spectrum disorder in the offspring
por: Afroz, Kazi Farhana, et al.
Publicado: (2019)

RORA and posttraumatic stress trajectories: main effects and interactions with childhood physical abuse history
por: Lowe, Sarah R, et al.
Publicado: (2015)

Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility
por: Benna, Clara, et al.
Publicado: (2021)

ERCC5 , HES6 and RORA are potential diagnostic markers of coronary artery disease
por: Bai, Zhifeng, et al.
Publicado: (2022)

CircGSK3B promotes RORA expression and suppresses gastric cancer progression through the prevention of EZH2 trans-inhibition
por: Ma, Xianxiong, et al.
Publicado: (2021)

Autism-like Behaviors in Male Juvenile Offspring after Maternal Glyphosate Exposure
por: Pu, Yaoyu, et al.
Publicado: (2021)

Maternal Levels of Cytokines in Early Pregnancy and Risk of Autism Spectrum Disorders in Offspring
por: Brynge, Martin, et al.
Publicado: (2022)

Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts
por: Hertz‐Picciotto, Irva, et al.
Publicado: (2022)

Investigation of Associations between NR1D1, RORA and RORB Genes and Bipolar Disorder
por: Lai, Yin-Chieh, et al.
Publicado: (2015)

Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study
por: Madley-Dowd, Paul, et al.
Publicado: (2022)

Maternal Diabetes Induces Immune Dysfunction in Autistic Offspring Through Oxidative Stress in Hematopoietic Stem Cells
por: Lu, Jianping, et al.
Publicado: (2020)

Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring
por: Hagberg, Katrina Wilcox, et al.
Publicado: (2018)

Maternal prepregnancy weight and gestational weight gain in association with autism and developmental disorders in offspring
por: Matias, Susana L., et al.
Publicado: (2021)

Maternal Serum Vitamin B12 during Pregnancy and Offspring Autism Spectrum Disorder
por: Sourander, Andre, et al.
Publicado: (2023)

The EIF4A3/CASC2/RORA Feedback Loop Regulates the Aggressive Phenotype in Glioblastomas
por: Zhao, Junshuang, et al.
Publicado: (2021)

Identification of TIMELESS and RORA as key clock molecules of non-small cell lung cancer and the comprehensive analysis
por: Xian, Haocheng, et al.
Publicado: (2022)

RORA alleviates LPS-induced apoptosis of renal epithelial cells by promoting PGC-1α transcription
por: Li, Dayong, et al.
Publicado: (2022)

The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed
por: Yiğit, Serbulent, et al.
Publicado: (2023)

lncRNA FGD5 antisense RNA 1 upregulates RORA to suppress hypoxic injury of human cardiomyocyte cells by inhibiting oxidative stress and apoptosis via miR-195
por: Cai, Xinyong, et al.
Publicado: (2020)

Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring
por: Banik, Avijit, et al.
Publicado: (2017)

The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut
por: Russell, Amber L., et al.
Publicado: (2023)

A Meta-Analysis of Maternal Smoking during Pregnancy and Autism Spectrum Disorder Risk in Offspring
por: Tang, Shiming, et al.
Publicado: (2015)

Maternal Body Mass Index and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysis
por: Wang, Ying, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_m40l1mjuakq1c1gbil7u3kjbic