eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling

Despite encouraging preclinical data, therapies to reduce ARDS mortality remains a globally unmet need, including during the COVID-19 pandemic. We previously identified extracellular nicotinamide phosphoribosyltransferase (eNAMPT) as a novel damage-associated molecular pattern protein (DAMP) via TLR...

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Detalles Bibliográficos
Autores principales: Bermudez, Tadeo, Sammani, Saad, Song, Jin H., Hernon, Vivian Reyes, Kempf, Carrie L., Garcia, Alexander N., Burt, Jessica, Hufford, Matthew, Camp, Sara M., Cress, Anne E., Desai, Ankit A., Natarajan, Viswanathan, Jacobson, Jeffrey R., Dudek, Steven M., Cancio, Leopoldo C., Alvarez, Julie, Rafikov, Ruslan, Li, Yansong, Zhang, Donna D., Casanova, Nancy G., Bime, Christian, Garcia, Joe G. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758770/
https://www.ncbi.nlm.nih.gov/pubmed/35027578
http://dx.doi.org/10.1038/s41598-021-04444-9

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