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A dynamically evolving war between autophagy and pathogenic microorganisms

Autophagy is an intracellular degradation process that maintains cellular homeostasis. It is essential for protecting organisms from environmental stress. Autophagy can help the host to eliminate invading pathogens, including bacteria, viruses, fungi, and parasites. However, pathogens have evolved m...

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Detalles Bibliográficos
Autores principales: ZHENG, Qianqian, DUAN, Liangwei, ZHANG, Yang, LI, Jiaoyang, ZHANG, Shiyu, WANG, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Zhejiang University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758936/
https://www.ncbi.nlm.nih.gov/pubmed/35029086
http://dx.doi.org/10.1631/jzus.B2100285
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author ZHENG, Qianqian
DUAN, Liangwei
ZHANG, Yang
LI, Jiaoyang
ZHANG, Shiyu
WANG, Hui
author_facet ZHENG, Qianqian
DUAN, Liangwei
ZHANG, Yang
LI, Jiaoyang
ZHANG, Shiyu
WANG, Hui
author_sort ZHENG, Qianqian
collection PubMed
description Autophagy is an intracellular degradation process that maintains cellular homeostasis. It is essential for protecting organisms from environmental stress. Autophagy can help the host to eliminate invading pathogens, including bacteria, viruses, fungi, and parasites. However, pathogens have evolved multiple strategies to interfere with autophagic signaling pathways or inhibit the fusion of autophagosomes with lysosomes to form autolysosomes. Moreover, host cell matrix degradation by different types of autophagy can be used for the proliferation and reproduction of pathogens. Thus, determining the roles and mechanisms of autophagy during pathogen infections will promote understanding of the mechanisms of pathogen‍‒‍host interactions and provide new strategies for the treatment of infectious diseases.
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spelling pubmed-87589362022-01-24 A dynamically evolving war between autophagy and pathogenic microorganisms ZHENG, Qianqian DUAN, Liangwei ZHANG, Yang LI, Jiaoyang ZHANG, Shiyu WANG, Hui J Zhejiang Univ Sci B Review Autophagy is an intracellular degradation process that maintains cellular homeostasis. It is essential for protecting organisms from environmental stress. Autophagy can help the host to eliminate invading pathogens, including bacteria, viruses, fungi, and parasites. However, pathogens have evolved multiple strategies to interfere with autophagic signaling pathways or inhibit the fusion of autophagosomes with lysosomes to form autolysosomes. Moreover, host cell matrix degradation by different types of autophagy can be used for the proliferation and reproduction of pathogens. Thus, determining the roles and mechanisms of autophagy during pathogen infections will promote understanding of the mechanisms of pathogen‍‒‍host interactions and provide new strategies for the treatment of infectious diseases. Zhejiang University Press 2022-01-15 /pmc/articles/PMC8758936/ /pubmed/35029086 http://dx.doi.org/10.1631/jzus.B2100285 Text en Copyright © Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature 2021
spellingShingle Review
ZHENG, Qianqian
DUAN, Liangwei
ZHANG, Yang
LI, Jiaoyang
ZHANG, Shiyu
WANG, Hui
A dynamically evolving war between autophagy and pathogenic microorganisms
title A dynamically evolving war between autophagy and pathogenic microorganisms
title_full A dynamically evolving war between autophagy and pathogenic microorganisms
title_fullStr A dynamically evolving war between autophagy and pathogenic microorganisms
title_full_unstemmed A dynamically evolving war between autophagy and pathogenic microorganisms
title_short A dynamically evolving war between autophagy and pathogenic microorganisms
title_sort dynamically evolving war between autophagy and pathogenic microorganisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758936/
https://www.ncbi.nlm.nih.gov/pubmed/35029086
http://dx.doi.org/10.1631/jzus.B2100285
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