An episomal DNA vector platform for the persistent genetic modification of pluripotent stem cells and their differentiated progeny

The genetic modification of stem cells (SCs) is typically achieved using integrating vectors, whose potential integrative genotoxicity and propensity for epigenetic silencing during differentiation limit their application. The genetic modification of cells should provide sustainable levels of transg...

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Detalles Bibliográficos
Autores principales: Roig-Merino, Alicia, Urban, Manuela, Bozza, Matthias, Peterson, Julia D., Bullen, Louise, Büchler-Schäff, Marleen, Stäble, Sina, van der Hoeven, Franciscus, Müller-Decker, Karin, McKay, Tristan R., Milsom, Michael D., Harbottle, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758943/
https://www.ncbi.nlm.nih.gov/pubmed/34942088
http://dx.doi.org/10.1016/j.stemcr.2021.11.011

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