ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends

Valence of animal pheromone blends can vary due to differences in relative abundance of individual components. For example, in C. elegans, whether a pheromone blend is perceived as “male” or “hermaphrodite” is determined by the ratio of concentrations of ascr#10 and ascr#3. The neuronal mechanisms t...

Descripción completa

Detalles Bibliográficos
Autores principales: Aprison, Erin Z., Ruvinsky, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758999/
https://www.ncbi.nlm.nih.gov/pubmed/35047764
http://dx.doi.org/10.17912/micropub.biology.000507
_version_ 1784633022605164544
author Aprison, Erin Z.
Ruvinsky, Ilya
author_facet Aprison, Erin Z.
Ruvinsky, Ilya
author_sort Aprison, Erin Z.
collection PubMed
description Valence of animal pheromone blends can vary due to differences in relative abundance of individual components. For example, in C. elegans, whether a pheromone blend is perceived as “male” or “hermaphrodite” is determined by the ratio of concentrations of ascr#10 and ascr#3. The neuronal mechanisms that evaluate this ratio are not currently understood. We present data that suggest that the function of guanylyl cyclase ODR-1 in AWB neurons is required for the effect of ascr#3 that counteracts the activity of ascr#10. This finding defines a new module in the neuronal mechanism that determines the sexual identity of C. elegans pheromone.
format Online
Article
Text
id pubmed-8758999
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Caltech Library
record_format MEDLINE/PubMed
spelling pubmed-87589992022-01-18 ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends Aprison, Erin Z. Ruvinsky, Ilya MicroPubl Biol New Finding Valence of animal pheromone blends can vary due to differences in relative abundance of individual components. For example, in C. elegans, whether a pheromone blend is perceived as “male” or “hermaphrodite” is determined by the ratio of concentrations of ascr#10 and ascr#3. The neuronal mechanisms that evaluate this ratio are not currently understood. We present data that suggest that the function of guanylyl cyclase ODR-1 in AWB neurons is required for the effect of ascr#3 that counteracts the activity of ascr#10. This finding defines a new module in the neuronal mechanism that determines the sexual identity of C. elegans pheromone. Caltech Library 2022-01-13 /pmc/articles/PMC8758999/ /pubmed/35047764 http://dx.doi.org/10.17912/micropub.biology.000507 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Aprison, Erin Z.
Ruvinsky, Ilya
ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends
title ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends
title_full ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends
title_fullStr ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends
title_full_unstemmed ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends
title_short ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends
title_sort odr-1 acts in awb neurons to determine the sexual identity of c. elegans pheromone blends
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8758999/
https://www.ncbi.nlm.nih.gov/pubmed/35047764
http://dx.doi.org/10.17912/micropub.biology.000507
work_keys_str_mv AT aprisonerinz odr1actsinawbneuronstodeterminethesexualidentityofceleganspheromoneblends
AT ruvinskyilya odr1actsinawbneuronstodeterminethesexualidentityofceleganspheromoneblends

Ejemplares similares