Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021

The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong’s COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test....

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Autores principales: Kwok, Shirley LL, Cheng, Samuel MS, Leung, Jennifer NS, Leung, Kathy, Lee, Cheuk-Kwong, Peiris, JS Malik, Wu, Joseph T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759113/
https://www.ncbi.nlm.nih.gov/pubmed/35027105
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.2.2101197
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author Kwok, Shirley LL
Cheng, Samuel MS
Leung, Jennifer NS
Leung, Kathy
Lee, Cheuk-Kwong
Peiris, JS Malik
Wu, Joseph T
author_facet Kwok, Shirley LL
Cheng, Samuel MS
Leung, Jennifer NS
Leung, Kathy
Lee, Cheuk-Kwong
Peiris, JS Malik
Wu, Joseph T
author_sort Kwok, Shirley LL
collection PubMed
description The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong’s COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test. The Comirnaty-vaccinated group’s (n = 593) antibody levels remained over the ELISA and sVNT positive cut-offs within the first 6 months. The CoronaVac-vaccinated group’s (n = 257) median antibody levels began to fall below the cut-offs 4 months after vaccination.
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spelling pubmed-87591132022-02-07 Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021 Kwok, Shirley LL Cheng, Samuel MS Leung, Jennifer NS Leung, Kathy Lee, Cheuk-Kwong Peiris, JS Malik Wu, Joseph T Euro Surveill Rapid Communication The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong’s COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test. The Comirnaty-vaccinated group’s (n = 593) antibody levels remained over the ELISA and sVNT positive cut-offs within the first 6 months. The CoronaVac-vaccinated group’s (n = 257) median antibody levels began to fall below the cut-offs 4 months after vaccination. European Centre for Disease Prevention and Control (ECDC) 2022-01-13 /pmc/articles/PMC8759113/ /pubmed/35027105 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.2.2101197 Text en This article is copyright of the authors or their affiliated institutions, 2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Kwok, Shirley LL
Cheng, Samuel MS
Leung, Jennifer NS
Leung, Kathy
Lee, Cheuk-Kwong
Peiris, JS Malik
Wu, Joseph T
Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
title Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
title_full Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
title_fullStr Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
title_full_unstemmed Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
title_short Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
title_sort waning antibody levels after covid-19 vaccination with mrna comirnaty and inactivated coronavac vaccines in blood donors, hong kong, april 2020 to october 2021
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759113/
https://www.ncbi.nlm.nih.gov/pubmed/35027105
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.2.2101197
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