Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy

Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very e...

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Autores principales: Hosseini, Reza, Sarvnaz, Hamzeh, Arabpour, Maedeh, Ramshe, Samira Molaei, Asef-Kabiri, Leila, Yousefi, Hassan, Akbari, Mohammad Esmaeil, Eskandari, Nahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759167/
https://www.ncbi.nlm.nih.gov/pubmed/35031075
http://dx.doi.org/10.1186/s12943-021-01492-7
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author Hosseini, Reza
Sarvnaz, Hamzeh
Arabpour, Maedeh
Ramshe, Samira Molaei
Asef-Kabiri, Leila
Yousefi, Hassan
Akbari, Mohammad Esmaeil
Eskandari, Nahid
author_facet Hosseini, Reza
Sarvnaz, Hamzeh
Arabpour, Maedeh
Ramshe, Samira Molaei
Asef-Kabiri, Leila
Yousefi, Hassan
Akbari, Mohammad Esmaeil
Eskandari, Nahid
author_sort Hosseini, Reza
collection PubMed
description Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very early and counteract the tumor development and metastasis without a need for additional activation. Based on this rationale, adoptive transfer of ex vivo expanded NK cells/NK cell lines, such as NK-92 cells, has attracted great attention and is widely studied as a promising immunotherapy for cancer treatment. However, by exploiting various strategies, including secretion of exosomes, cancer cells are able to subvert NK cell responses. This paper reviews the roles of TDEs in cancer-induced NK cells impairments with mechanistic insights. The clinical significance and potential approaches to nullify the effects of TDEs on NK cells in cancer immunotherapy are also discussed.
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spelling pubmed-87591672022-01-18 Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy Hosseini, Reza Sarvnaz, Hamzeh Arabpour, Maedeh Ramshe, Samira Molaei Asef-Kabiri, Leila Yousefi, Hassan Akbari, Mohammad Esmaeil Eskandari, Nahid Mol Cancer Review Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very early and counteract the tumor development and metastasis without a need for additional activation. Based on this rationale, adoptive transfer of ex vivo expanded NK cells/NK cell lines, such as NK-92 cells, has attracted great attention and is widely studied as a promising immunotherapy for cancer treatment. However, by exploiting various strategies, including secretion of exosomes, cancer cells are able to subvert NK cell responses. This paper reviews the roles of TDEs in cancer-induced NK cells impairments with mechanistic insights. The clinical significance and potential approaches to nullify the effects of TDEs on NK cells in cancer immunotherapy are also discussed. BioMed Central 2022-01-14 /pmc/articles/PMC8759167/ /pubmed/35031075 http://dx.doi.org/10.1186/s12943-021-01492-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Hosseini, Reza
Sarvnaz, Hamzeh
Arabpour, Maedeh
Ramshe, Samira Molaei
Asef-Kabiri, Leila
Yousefi, Hassan
Akbari, Mohammad Esmaeil
Eskandari, Nahid
Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
title Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
title_full Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
title_fullStr Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
title_full_unstemmed Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
title_short Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
title_sort cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759167/
https://www.ncbi.nlm.nih.gov/pubmed/35031075
http://dx.doi.org/10.1186/s12943-021-01492-7
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