Secreted osteopontin from CD4(+) T cells limits acute graft-versus-host disease

Osteopontin (OPN) has been considered a potential biomarker of graft-versus-host disease (GVHD). However, the function of OPN in GVHD is still elusive. Using a mouse model of acute GVHD (aGVHD), we report that OPN generated by CD4(+) T cells is sufficient to exert a beneficial effect in controlling...

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Detalles Bibliográficos
Autores principales: Aggarwal, Nupur, Deerhake, M. Elizabeth, DiPalma, Devon, Shahi, Shailesh K., Gaggioli, Margaret R., Mangalam, Ashutosh K., Shinohara, Mari L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759344/
https://www.ncbi.nlm.nih.gov/pubmed/34965439
http://dx.doi.org/10.1016/j.celrep.2021.110170

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