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Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience

BACKGROUND. The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date,...

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Autores principales: Jayasekera, Channa R., Vikram, Holenarasipur R., Rifat, Zeeshan, Wagler, Josiah, Okubo, Keita, Braaksma, Brandon R., Harbell, Jack W., Jadlowiec, Caroline C., Katariya, Nitin N., Mathur, Amit K., Moss, Adyr, Reddy, K. Sudhakar, Singer, Andrew, Orenstein, Robert, Saling, Christopher F., Seville, Maria T., Mour, Girish K., Vargas, Hugo E., Byrne, Thomas J., Hewitt, Winston R., Aqel, Bashar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759616/
https://www.ncbi.nlm.nih.gov/pubmed/35047665
http://dx.doi.org/10.1097/TXD.0000000000001286
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author Jayasekera, Channa R.
Vikram, Holenarasipur R.
Rifat, Zeeshan
Wagler, Josiah
Okubo, Keita
Braaksma, Brandon R.
Harbell, Jack W.
Jadlowiec, Caroline C.
Katariya, Nitin N.
Mathur, Amit K.
Moss, Adyr
Reddy, K. Sudhakar
Singer, Andrew
Orenstein, Robert
Saling, Christopher F.
Seville, Maria T.
Mour, Girish K.
Vargas, Hugo E.
Byrne, Thomas J.
Hewitt, Winston R.
Aqel, Bashar A.
author_facet Jayasekera, Channa R.
Vikram, Holenarasipur R.
Rifat, Zeeshan
Wagler, Josiah
Okubo, Keita
Braaksma, Brandon R.
Harbell, Jack W.
Jadlowiec, Caroline C.
Katariya, Nitin N.
Mathur, Amit K.
Moss, Adyr
Reddy, K. Sudhakar
Singer, Andrew
Orenstein, Robert
Saling, Christopher F.
Seville, Maria T.
Mour, Girish K.
Vargas, Hugo E.
Byrne, Thomas J.
Hewitt, Winston R.
Aqel, Bashar A.
author_sort Jayasekera, Channa R.
collection PubMed
description BACKGROUND. The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission. METHODS. Abdominal solid organs from SARS-CoV-2–infected donors were transplanted into uninfected recipients. RESULTS. Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2–infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA. CONCLUSIONS. Transplanting nonlung organs from SARS-CoV-2–infected donors into uninfected recipients demonstrated no evidence of virus transmission.
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spelling pubmed-87596162022-01-18 Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience Jayasekera, Channa R. Vikram, Holenarasipur R. Rifat, Zeeshan Wagler, Josiah Okubo, Keita Braaksma, Brandon R. Harbell, Jack W. Jadlowiec, Caroline C. Katariya, Nitin N. Mathur, Amit K. Moss, Adyr Reddy, K. Sudhakar Singer, Andrew Orenstein, Robert Saling, Christopher F. Seville, Maria T. Mour, Girish K. Vargas, Hugo E. Byrne, Thomas J. Hewitt, Winston R. Aqel, Bashar A. Transplant Direct Infectious Disease BACKGROUND. The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission. METHODS. Abdominal solid organs from SARS-CoV-2–infected donors were transplanted into uninfected recipients. RESULTS. Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2–infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA. CONCLUSIONS. Transplanting nonlung organs from SARS-CoV-2–infected donors into uninfected recipients demonstrated no evidence of virus transmission. Lippincott Williams & Wilkins 2022-01-13 /pmc/articles/PMC8759616/ /pubmed/35047665 http://dx.doi.org/10.1097/TXD.0000000000001286 Text en Copyright © 2022 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Infectious Disease
Jayasekera, Channa R.
Vikram, Holenarasipur R.
Rifat, Zeeshan
Wagler, Josiah
Okubo, Keita
Braaksma, Brandon R.
Harbell, Jack W.
Jadlowiec, Caroline C.
Katariya, Nitin N.
Mathur, Amit K.
Moss, Adyr
Reddy, K. Sudhakar
Singer, Andrew
Orenstein, Robert
Saling, Christopher F.
Seville, Maria T.
Mour, Girish K.
Vargas, Hugo E.
Byrne, Thomas J.
Hewitt, Winston R.
Aqel, Bashar A.
Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience
title Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience
title_full Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience
title_fullStr Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience
title_full_unstemmed Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience
title_short Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience
title_sort solid organ transplantation from sars-cov-2–infected donors to uninfected recipients: a single-center experience
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759616/
https://www.ncbi.nlm.nih.gov/pubmed/35047665
http://dx.doi.org/10.1097/TXD.0000000000001286
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