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A G-protein-biased S1P(1) agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome

AIM: Heart failure with preserved ejection fraction (HFpEF) is a major cause of death worldwide with no approved treatment. Left ventricular hypertrophy (LVH) and diastolic dysfunction represent the structural and functional components of HFpEF, respectively. Endothelial dysfunction is prevalent in...

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Detalles Bibliográficos
Autores principales:	Evaristi, Maria Francesca, Poirier, Bruno, Chénedé, Xavier, Lefebvre, Anne-Marie, Roccon, Alain, Gillot, Florence, Beeské, Sandra, Corbier, Alain, Pruniaux-Harnist, Marie-Pierre, Janiak, Philip, Parkar, Ashfaq A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759645/ https://www.ncbi.nlm.nih.gov/pubmed/35030174 http://dx.doi.org/10.1371/journal.pone.0257929

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