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Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease

Inborn errors of nucleic acid metabolism often cause aberrant activation of nucleic acid sensing pathways, leading to autoimmune or autoinflammatory diseases. The SKIV2L RNA exosome is cytoplasmic RNA degradation machinery that was thought to be essential for preventing the self-RNA–mediated interfe...

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Detalles Bibliográficos
Autores principales:	Yang, Kun, Han, Jie, Asada, Mayumi, Gill, Jennifer G., Park, Jason Y., Sathe, Meghana N., Gattineni, Jyothsna, Wright, Tracey, Wysocki, Christian A., de la Morena, M. Teresa, Garza, Luis A., Yan, Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759780/ https://www.ncbi.nlm.nih.gov/pubmed/35040435 http://dx.doi.org/10.1172/JCI146176

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