Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy

Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective cellular proteostasis. However, the complexity of autophagy may prevent the full appreciation of how its modulation could be used as a therapeutic strategy in disease management. Here, we define a molecular pathw...

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Detalles Bibliográficos
Autores principales: van de Veerdonk, Frank L., Renga, Giorgia, Pariano, Marilena, Bellet, Marina M., Servillo, Giuseppe, Fallarino, Francesca, De Luca, Antonella, Iannitti, Rossana G., Piobbico, Danilo, Gargaro, Marco, Manni, Giorgia, D’Onofrio, Fiorella, Stincardini, Claudia, Sforna, Luigi, Borghi, Monica, Castelli, Marilena, Pieroni, Stefania, Oikonomou, Vasileios, Villella, Valeria R., Puccetti, Matteo, Giovagnoli, Stefano, Galarini, Roberta, Barola, Carolina, Maiuri, Luigi, Della Fazia, Maria Agnese, Cellini, Barbara, Talesa, Vincenzo Nicola, Dinarello, Charles A., Costantini, Claudio, Romani, Luigina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759782/
https://www.ncbi.nlm.nih.gov/pubmed/34847078
http://dx.doi.org/10.1172/JCI144983

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