Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac injury, we demonstrate that cardiomyocytes play a pivotal role in heart repair by regulating nucleot...

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Detalles Bibliográficos
Autores principales: Li, Shen, Yokota, Tomohiro, Wang, Ping, ten Hoeve, Johanna, Ma, Feiyang, Le, Thuc M., Abt, Evan R., Zhou, Yonggang, Wu, Rimao, Nanthavongdouangsy, Maxine, Rodriguez, Abraham, Wang, Yijie, Lin, Yen-Ju, Muranaka, Hayato, Sharpley, Mark, Braddock, Demetrios T., MacRae, Vicky E., Banerjee, Utpal, Chiou, Pei-Yu, Seldin, Marcus, Huang, Dian, Teitell, Michael, Gertsman, Ilya, Jung, Michael, Bensinger, Steven J., Damoiseaux, Robert, Faull, Kym, Pellegrini, Matteo, Lusis, Aldons J., Graeber, Thomas G., Radu, Caius G., Deb, Arjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759793/
https://www.ncbi.nlm.nih.gov/pubmed/34813507
http://dx.doi.org/10.1172/JCI149711

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