Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1

T cell polyfunctionality is a hallmark of protective immunity against pathogens and cancer, yet the molecular mechanism governing it remains mostly elusive. We found that canonical Wnt agonists inhibited human memory CD8(+) T cell differentiation while simultaneously promoting the generation of high...

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Detalles Bibliográficos
Autores principales: Sung, Bo-Yi, Lin, Yi-Hsin, Kong, Qiongman, Shah, Pali D., Glick Bieler, Joan, Palmer, Scott, Weinhold, Kent J., Chang, Hong-Ru, Huang, Hailiang, Avery, Robin K., Schneck, Jonathan, Chiu, Yen-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759796/
https://www.ncbi.nlm.nih.gov/pubmed/35040433
http://dx.doi.org/10.1172/JCI140508

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