The Mitragyna speciosa (Kratom) Genome: a resource for data-mining potent pharmaceuticals that impact human health

Mitragyna speciosa (kratom) produces numerous compounds with pharmaceutical properties including the production of bioactive monoterpene indole and oxindole alkaloids. Using a linked-read approach, a 1,122,519,462 bp draft assembly of M. speciosa “Rifat” was generated with an N50 scaffold size of 1,...

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Detalles Bibliográficos
Autores principales: Brose, Julia, Lau, Kin H, Dang, Thu Thuy Thi, Hamilton, John P, Martins, Lívia do Vale, Hamberger, Britta, Hamberger, Bjoern, Jiang, Jiming, O’Connor, Sarah E, Buell, C Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759815/
https://www.ncbi.nlm.nih.gov/pubmed/33677570
http://dx.doi.org/10.1093/g3journal/jkab058
Descripción
Sumario:Mitragyna speciosa (kratom) produces numerous compounds with pharmaceutical properties including the production of bioactive monoterpene indole and oxindole alkaloids. Using a linked-read approach, a 1,122,519,462 bp draft assembly of M. speciosa “Rifat” was generated with an N50 scaffold size of 1,020,971 bp and an N50 contig size of 70,448 bp that encodes 55,746 genes. Chromosome counting revealed that “Rifat” is a tetraploid with a base chromosome number of 11, which was further corroborated by orthology and syntenic analysis of the genome. Analysis of genes and clusters involved in specialized metabolism revealed genes putatively involved in alkaloid biosynthesis. Access to the genome of M. speciosa will facilitate an improved understanding of alkaloid biosynthesis and accelerate the production of bioactive alkaloids in heterologous hosts.

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