Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death

Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted prolonged polyQ tract. We previously identified TRMT2A as a strong modifier of polyQ-induced toxicity in an unbiased large-scale screen in Drosophila...

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Detalles Bibliográficos
Autores principales: Margreiter, Michael A, Witzenberger, Monika, Wasser, Yasmine, Davydova, Elena, Janowski, Robert, Metz, Jonas, Habib, Pardes, Sahnoun, Sabri E.M., Sobisch, Carina, Poma, Benedetta, Palomino-Hernandez, Oscar, Wagner, Mirko, Carell, Thomas, Jon Shah, N., Schulz, Jörg B., Niessing, Dierk, Voigt, Aaron, Rossetti, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759985/
https://www.ncbi.nlm.nih.gov/pubmed/35070167
http://dx.doi.org/10.1016/j.csbj.2021.12.029

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