Cargando…

Belimumab in Lupus Nephritis: A Systematic Review and Meta-Analysis

Belimumab is a recombinant human IgG-1λ monoclonal antibody. It inhibits the B-cell activating factor (BAFF) and is approved for patients with systemic lupus erythematosus (SLE) older than five years with positive autoantibody. We aimed to evaluate the role of belimumab in the maintenance phase of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shrestha, Sanjeev, Budhathoki, Pravash, Adhikari, Yuvraj, Marasini, Anupama, Bhandari, Shakar, Mir, Wasey Ali Yadullahi, Shrestha, Dhan B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760003/
https://www.ncbi.nlm.nih.gov/pubmed/35047277
http://dx.doi.org/10.7759/cureus.20440
Descripción
Sumario:Belimumab is a recombinant human IgG-1λ monoclonal antibody. It inhibits the B-cell activating factor (BAFF) and is approved for patients with systemic lupus erythematosus (SLE) older than five years with positive autoantibody. We aimed to evaluate the role of belimumab in the maintenance phase of treatment for lupus nephritis (LN). PubMed, PubMed Central (PMC), Cochrane Library, and Embase were searched using appropriate keywords. The screening of title and abstract was done in Covidence, followed by data extraction of the relevant studies based on inclusion criteria. Review manager (RevMan 5.4) was used for data analysis with random or fixed effects model based on heterogeneities. Two randomized controlled trials were included in the quantitative analysis. There were 1.71 times higher odds of complete renal response in the belimumab group than in the control group (odds ratio (OR), 1.71; 95% confidence interval (CI), 1.12-2.60; I-square (I(2)) ​​​​= 0%). Similarly, there was 34% lower odds for having no response among the belimumab group (OR, 0.66; 95% CI, 0.45-0.96; I(2 )= 0%). No significant differences between the two groups were observed for the occurrence of treatment-related adverse events (TRAEs) (OR, 1.07; 95% CI, 0.74-1.56; I(2) = 0%), treatment-related serious adverse events (OR, 0.54; 95% CI, 0.15-1.96; I(2) = 68%), and treatment-related infections (OR, 0.65; 95% CI, 0.27-1.55; I(2) = 21%).Therefore, belimumab and standard treatment were instrumental for beneficial renal response in patients with lupus nephritis and were not associated with increased odds of adverse effect compared with the standard treatment alone.