Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders

Mutations in SHANK genes play an undisputed role in neuropsychiatric disorders. Until now, research has focused on the postsynaptic function of SHANKs, and prominent postsynaptic alterations in glutamatergic signal transmission have been reported in Shank KO mouse models. Recent studies have also su...

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Detalles Bibliográficos
Autores principales: Eltokhi, Ahmed, Gonzalez-Lozano, Miguel A., Oettl, Lars-Lennart, Rozov, Andrey, Pitzer, Claudia, Röth, Ralph, Berkel, Simone, Hüser, Markus, Harten, Aliona, Kelsch, Wolfgang, Smit, August B., Rappold, Gudrun A., Sprengel, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760046/
https://www.ncbi.nlm.nih.gov/pubmed/34021263
http://dx.doi.org/10.1038/s41380-021-01140-y

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