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Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and...

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Autores principales: McWhinney, Sean R., Abé, Christoph, Alda, Martin, Benedetti, Francesco, Bøen, Erlend, del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Dannlowski, Udo, Díaz-Zuluaga, Ana M., Elvsåshagen, Torbjørn, Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C. M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Kircher, Tilo T. J., Krug, Axel, Kuplicki, Rayus T., Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, McDonald, Colm, McPhilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M. T., Mitchell, Philip B., Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia-Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G., Roberts, Gloria, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R., Sim, Kang, Stein, Dan J., Stein, Frederike, Temmingh, Henk S., Thiel, Katharina, van Haren, Neeltje E. M., Gestel, Holly Van, Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N., Ching, Christopher R. K., Andreassen, Ole, Thompson, Paul M., Hajek, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760047/
https://www.ncbi.nlm.nih.gov/pubmed/33863996
http://dx.doi.org/10.1038/s41380-021-01098-x
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author McWhinney, Sean R.
Abé, Christoph
Alda, Martin
Benedetti, Francesco
Bøen, Erlend
del Mar Bonnin, Caterina
Borgers, Tiana
Brosch, Katharina
Canales-Rodríguez, Erick J.
Cannon, Dara M.
Dannlowski, Udo
Díaz-Zuluaga, Ana M.
Elvsåshagen, Torbjørn
Eyler, Lisa T.
Fullerton, Janice M.
Goikolea, Jose M.
Goltermann, Janik
Grotegerd, Dominik
Haarman, Bartholomeus C. M.
Hahn, Tim
Howells, Fleur M.
Ingvar, Martin
Kircher, Tilo T. J.
Krug, Axel
Kuplicki, Rayus T.
Landén, Mikael
Lemke, Hannah
Liberg, Benny
Lopez-Jaramillo, Carlos
Malt, Ulrik F.
Martyn, Fiona M.
Mazza, Elena
McDonald, Colm
McPhilemy, Genevieve
Meier, Sandra
Meinert, Susanne
Meller, Tina
Melloni, Elisa M. T.
Mitchell, Philip B.
Nabulsi, Leila
Nenadic, Igor
Opel, Nils
Ophoff, Roel A.
Overs, Bronwyn J.
Pfarr, Julia-Katharina
Pineda-Zapata, Julian A.
Pomarol-Clotet, Edith
Raduà, Joaquim
Repple, Jonathan
Richter, Maike
Ringwald, Kai G.
Roberts, Gloria
Salvador, Raymond
Savitz, Jonathan
Schmitt, Simon
Schofield, Peter R.
Sim, Kang
Stein, Dan J.
Stein, Frederike
Temmingh, Henk S.
Thiel, Katharina
van Haren, Neeltje E. M.
Gestel, Holly Van
Vargas, Cristian
Vieta, Eduard
Vreeker, Annabel
Waltemate, Lena
Yatham, Lakshmi N.
Ching, Christopher R. K.
Andreassen, Ole
Thompson, Paul M.
Hajek, Tomas
author_facet McWhinney, Sean R.
Abé, Christoph
Alda, Martin
Benedetti, Francesco
Bøen, Erlend
del Mar Bonnin, Caterina
Borgers, Tiana
Brosch, Katharina
Canales-Rodríguez, Erick J.
Cannon, Dara M.
Dannlowski, Udo
Díaz-Zuluaga, Ana M.
Elvsåshagen, Torbjørn
Eyler, Lisa T.
Fullerton, Janice M.
Goikolea, Jose M.
Goltermann, Janik
Grotegerd, Dominik
Haarman, Bartholomeus C. M.
Hahn, Tim
Howells, Fleur M.
Ingvar, Martin
Kircher, Tilo T. J.
Krug, Axel
Kuplicki, Rayus T.
Landén, Mikael
Lemke, Hannah
Liberg, Benny
Lopez-Jaramillo, Carlos
Malt, Ulrik F.
Martyn, Fiona M.
Mazza, Elena
McDonald, Colm
McPhilemy, Genevieve
Meier, Sandra
Meinert, Susanne
Meller, Tina
Melloni, Elisa M. T.
Mitchell, Philip B.
Nabulsi, Leila
Nenadic, Igor
Opel, Nils
Ophoff, Roel A.
Overs, Bronwyn J.
Pfarr, Julia-Katharina
Pineda-Zapata, Julian A.
Pomarol-Clotet, Edith
Raduà, Joaquim
Repple, Jonathan
Richter, Maike
Ringwald, Kai G.
Roberts, Gloria
Salvador, Raymond
Savitz, Jonathan
Schmitt, Simon
Schofield, Peter R.
Sim, Kang
Stein, Dan J.
Stein, Frederike
Temmingh, Henk S.
Thiel, Katharina
van Haren, Neeltje E. M.
Gestel, Holly Van
Vargas, Cristian
Vieta, Eduard
Vreeker, Annabel
Waltemate, Lena
Yatham, Lakshmi N.
Ching, Christopher R. K.
Andreassen, Ole
Thompson, Paul M.
Hajek, Tomas
author_sort McWhinney, Sean R.
collection PubMed
description Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles  and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
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spelling pubmed-87600472022-01-26 Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals McWhinney, Sean R. Abé, Christoph Alda, Martin Benedetti, Francesco Bøen, Erlend del Mar Bonnin, Caterina Borgers, Tiana Brosch, Katharina Canales-Rodríguez, Erick J. Cannon, Dara M. Dannlowski, Udo Díaz-Zuluaga, Ana M. Elvsåshagen, Torbjørn Eyler, Lisa T. Fullerton, Janice M. Goikolea, Jose M. Goltermann, Janik Grotegerd, Dominik Haarman, Bartholomeus C. M. Hahn, Tim Howells, Fleur M. Ingvar, Martin Kircher, Tilo T. J. Krug, Axel Kuplicki, Rayus T. Landén, Mikael Lemke, Hannah Liberg, Benny Lopez-Jaramillo, Carlos Malt, Ulrik F. Martyn, Fiona M. Mazza, Elena McDonald, Colm McPhilemy, Genevieve Meier, Sandra Meinert, Susanne Meller, Tina Melloni, Elisa M. T. Mitchell, Philip B. Nabulsi, Leila Nenadic, Igor Opel, Nils Ophoff, Roel A. Overs, Bronwyn J. Pfarr, Julia-Katharina Pineda-Zapata, Julian A. Pomarol-Clotet, Edith Raduà, Joaquim Repple, Jonathan Richter, Maike Ringwald, Kai G. Roberts, Gloria Salvador, Raymond Savitz, Jonathan Schmitt, Simon Schofield, Peter R. Sim, Kang Stein, Dan J. Stein, Frederike Temmingh, Henk S. Thiel, Katharina van Haren, Neeltje E. M. Gestel, Holly Van Vargas, Cristian Vieta, Eduard Vreeker, Annabel Waltemate, Lena Yatham, Lakshmi N. Ching, Christopher R. K. Andreassen, Ole Thompson, Paul M. Hajek, Tomas Mol Psychiatry Article Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles  and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression. Nature Publishing Group UK 2021-04-16 2021 /pmc/articles/PMC8760047/ /pubmed/33863996 http://dx.doi.org/10.1038/s41380-021-01098-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
McWhinney, Sean R.
Abé, Christoph
Alda, Martin
Benedetti, Francesco
Bøen, Erlend
del Mar Bonnin, Caterina
Borgers, Tiana
Brosch, Katharina
Canales-Rodríguez, Erick J.
Cannon, Dara M.
Dannlowski, Udo
Díaz-Zuluaga, Ana M.
Elvsåshagen, Torbjørn
Eyler, Lisa T.
Fullerton, Janice M.
Goikolea, Jose M.
Goltermann, Janik
Grotegerd, Dominik
Haarman, Bartholomeus C. M.
Hahn, Tim
Howells, Fleur M.
Ingvar, Martin
Kircher, Tilo T. J.
Krug, Axel
Kuplicki, Rayus T.
Landén, Mikael
Lemke, Hannah
Liberg, Benny
Lopez-Jaramillo, Carlos
Malt, Ulrik F.
Martyn, Fiona M.
Mazza, Elena
McDonald, Colm
McPhilemy, Genevieve
Meier, Sandra
Meinert, Susanne
Meller, Tina
Melloni, Elisa M. T.
Mitchell, Philip B.
Nabulsi, Leila
Nenadic, Igor
Opel, Nils
Ophoff, Roel A.
Overs, Bronwyn J.
Pfarr, Julia-Katharina
Pineda-Zapata, Julian A.
Pomarol-Clotet, Edith
Raduà, Joaquim
Repple, Jonathan
Richter, Maike
Ringwald, Kai G.
Roberts, Gloria
Salvador, Raymond
Savitz, Jonathan
Schmitt, Simon
Schofield, Peter R.
Sim, Kang
Stein, Dan J.
Stein, Frederike
Temmingh, Henk S.
Thiel, Katharina
van Haren, Neeltje E. M.
Gestel, Holly Van
Vargas, Cristian
Vieta, Eduard
Vreeker, Annabel
Waltemate, Lena
Yatham, Lakshmi N.
Ching, Christopher R. K.
Andreassen, Ole
Thompson, Paul M.
Hajek, Tomas
Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
title Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
title_full Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
title_fullStr Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
title_full_unstemmed Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
title_short Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
title_sort association between body mass index and subcortical brain volumes in bipolar disorders–enigma study in 2735 individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760047/
https://www.ncbi.nlm.nih.gov/pubmed/33863996
http://dx.doi.org/10.1038/s41380-021-01098-x
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