Cargando…

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound state. How cells process trapped PARP1 remains unclear. Using wild-type and a trapping-deficient PARP1 mutant combined with rapid immunopreci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krastev, Dragomir B., Li, Shudong, Sun, Yilun, Wicks, Andrew J., Hoslett, Gwendoline, Weekes, Daniel, Badder, Luned M., Knight, Eleanor G., Marlow, Rebecca, Pardo, Mercedes Calvo, Yu, Lu, Talele, Tanaji T., Bartek, Jiri, Choudhary, Jyoti S., Pommier, Yves, Pettitt, Stephen J., Tutt, Andrew N. J., Ramadan, Kristijan, Lord, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760077/ https://www.ncbi.nlm.nih.gov/pubmed/35013556 http://dx.doi.org/10.1038/s41556-021-00807-6

Ejemplares similares

Opinion: PARP inhibitors in cancer—what do we still need to know?
por: Wicks, Andrew J., et al.
Publicado: (2022)

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
por: Bajrami, Ilirjana, et al.
Publicado: (2021)

A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant
por: Pettitt, Stephen J., et al.
Publicado: (2023)

Role of p97/VCP (Cdc48) in genome stability
por: Vaz, Bruno, et al.
Publicado: (2013)

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
por: Pettitt, Stephen J., et al.
Publicado: (2018)

The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks
por: Torrecilla, Ignacio, et al.
Publicado: (2017)

A decade of clinical development of PARP inhibitors in perspective
por: Mateo, J, et al.
Publicado: (2019)

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets
por: Krastev, Dragomir B., et al.
Publicado: (2018)

Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts
por: Morten, Karl J, et al.
Publicado: (2013)

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
por: Fielden, John, et al.
Publicado: (2020)

Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains
por: Talele, Tanaji T, et al.
Publicado: (2009)

Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity
por: Puumalainen, Marjo-Riitta, et al.
Publicado: (2014)

Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance
por: Tarantino, Dalia, et al.
Publicado: (2022)

The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
por: Singh, Abhay Narayan, et al.
Publicado: (2019)

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
por: Zatreanu, Diana, et al.
Publicado: (2021)

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity
por: Frankum, Jessica, et al.
Publicado: (2015)

Pharmacophore Modeling of Nilotinib as an Inhibitor of ATP-Binding Cassette Drug Transporters and BCR-ABL Kinase Using a Three-Dimensional Quantitative Structure–Activity Relationship Approach
por: Shukla, Suneet, et al.
Publicado: (2014)

Access 97
por: García Núñez, Pablo J.
Publicado: (1997)

Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors
por: Patel, Maulik R., et al.
Publicado: (2014)

A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies Parp1 as a Mediator of Olaparib Toxicity
por: Pettitt, Stephen J., et al.
Publicado: (2013)

PSB timing 97
por: Cyvoct, G, et al.
Publicado: (1997)

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
por: Kilgas, Susan, et al.
Publicado: (2021)

In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates
por: AbdelKhalek, Ahmed, et al.
Publicado: (2016)

Microsoft Excel 97 : soluciones instantáneas
por: Nielsen, Joyce J.
Publicado: (1997)

Microsoft Excel 97 visual
por: Marmel, Elaine J.
Publicado: (1997)

Beyond DNA repair: the novel immunological potential of PARP inhibitors
por: Chabanon, Roman M., et al.
Publicado: (2019)

Lamellarin O, a Pyrrole Alkaloid from an Australian Marine Sponge, Ianthella sp., Reverses BCRP Mediated Drug Resistance in Cancer Cells
por: Huang, Xiao-Cong, et al.
Publicado: (2014)

Strong and Electroweak Matter '97 Conference : SEWM '97
por: Collective
Publicado: (1997)

Cancer in The Gambia: 1988–97
por: Bah, E, et al.
Publicado: (2001)

PS 97
Publicado: (1997)

Excel 97
por: Vázquez Jiménez, Susana
Publicado: (1997)

Excel 97
por: Tiznado Santana, Marco Antonio
Publicado: (1997)

Ramping '97
por: Jonker, M
Publicado: (1998)

WAIT '97
Publicado: (1997)

YERAC '97
Publicado: (1997)

Lasers '97
Publicado: (1997)

Supercomputing '97
por: Collective
Publicado: (1997)

WA97
por: Königsmann, K C
Publicado: (1995)

Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial
por: Carreira, Suzanne, et al.
Publicado: (2021)

Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development
por: Dana, Dibyendu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vl2k8fup0s9fm4m54jr7gshr9e