A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2

Currently, the world is facing a pandemic of the new coronavirus SARS-CoV-2 that causes COVID-19. Identifying key targets in the viral infection lifecycle is urgently needed for designing therapeutic strategies to combat the virus. Furin is a subtilisin-like proprotein convertase with diverse cellul...

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Detalles Bibliográficos
Autores principales: Devi, Kasi Pandima, Pourkarim, Mahmoud Reza, Thijssen, Marijn, Sureda, Antoni, Khayatkashani, Maryam, Cismaru, Cosmin Andrei, Neagoe, Ioana Berindan, Habtemariam, Solomon, Razmjouei, Soha, Khayat Kashani, Hamid Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760129/
https://www.ncbi.nlm.nih.gov/pubmed/35031970
http://dx.doi.org/10.1007/s43440-021-00344-x
Descripción
Sumario:Currently, the world is facing a pandemic of the new coronavirus SARS-CoV-2 that causes COVID-19. Identifying key targets in the viral infection lifecycle is urgently needed for designing therapeutic strategies to combat the virus. Furin is a subtilisin-like proprotein convertase with diverse cellular functions. Emerging evidence suggests that furin plays a critical role in the activation and/or infectivity of SARS-CoV-2. In this perspective, we discuss the potential role of furin in the entry SARS-CoV-2 into host cells. Furthermore, we evaluate available peptide and non-peptide furin inhibitors and potential outcomes, including immune responses.

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