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Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants

The evolutionary conserved Polycomb Group (PcG) repressive system comprises two central protein complexes, PcG repressive complex 1 (PRC1) and PRC2. These complexes, through the incorporation of histone modifications on chromatin, have an essential role in the normal development of eukaryotes. In re...

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Autores principales: Baile, Fernando, Gómez-Zambrano, Ángeles, Calonje, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760139/
https://www.ncbi.nlm.nih.gov/pubmed/35059633
http://dx.doi.org/10.1016/j.xplc.2021.100267
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author Baile, Fernando
Gómez-Zambrano, Ángeles
Calonje, Myriam
author_facet Baile, Fernando
Gómez-Zambrano, Ángeles
Calonje, Myriam
author_sort Baile, Fernando
collection PubMed
description The evolutionary conserved Polycomb Group (PcG) repressive system comprises two central protein complexes, PcG repressive complex 1 (PRC1) and PRC2. These complexes, through the incorporation of histone modifications on chromatin, have an essential role in the normal development of eukaryotes. In recent years, a significant effort has been made to characterize these complexes in the different kingdoms, and despite there being remarkable functional and mechanistic conservation, some key molecular principles have diverged. In this review, we discuss current views on the function of plant PcG complexes. We compare the composition of PcG complexes between animals and plants, highlight the role of recently identified plant PcG accessory proteins, and discuss newly revealed roles of known PcG partners. We also examine the mechanisms by which the repression is achieved and how these complexes are recruited to target genes. Finally, we consider the possible role of some plant PcG proteins in mediating local and long-range chromatin interactions and, thus, shaping chromatin 3D architecture.
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spelling pubmed-87601392022-01-19 Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants Baile, Fernando Gómez-Zambrano, Ángeles Calonje, Myriam Plant Commun Review Article The evolutionary conserved Polycomb Group (PcG) repressive system comprises two central protein complexes, PcG repressive complex 1 (PRC1) and PRC2. These complexes, through the incorporation of histone modifications on chromatin, have an essential role in the normal development of eukaryotes. In recent years, a significant effort has been made to characterize these complexes in the different kingdoms, and despite there being remarkable functional and mechanistic conservation, some key molecular principles have diverged. In this review, we discuss current views on the function of plant PcG complexes. We compare the composition of PcG complexes between animals and plants, highlight the role of recently identified plant PcG accessory proteins, and discuss newly revealed roles of known PcG partners. We also examine the mechanisms by which the repression is achieved and how these complexes are recruited to target genes. Finally, we consider the possible role of some plant PcG proteins in mediating local and long-range chromatin interactions and, thus, shaping chromatin 3D architecture. Elsevier 2021-11-26 /pmc/articles/PMC8760139/ /pubmed/35059633 http://dx.doi.org/10.1016/j.xplc.2021.100267 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Baile, Fernando
Gómez-Zambrano, Ángeles
Calonje, Myriam
Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants
title Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants
title_full Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants
title_fullStr Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants
title_full_unstemmed Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants
title_short Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants
title_sort roles of polycomb complexes in regulating gene expression and chromatin structure in plants
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760139/
https://www.ncbi.nlm.nih.gov/pubmed/35059633
http://dx.doi.org/10.1016/j.xplc.2021.100267
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