Cargando…

Evaluation of the novel vaginal contraceptive agent PPCM in preclinical studies using sperm hyaluronan binding and acrosome status assays

BACKGROUND: Polyphenylene carboxymethylene (PPCM) sodium salt is a promising multipurpose technology for prevention of both sexually transmitted infections (STIs) and pregnancy. In preclinical studies, PPCM has demonstrated significant (1) antimicrobial activity against several important viral and b...

Descripción completa

Detalles Bibliográficos
Autores principales:	North, Barbara B., Weitzel, Mary B., Waller, Donald P., Birch, William X., Feathergill, Kenneth A., Birch, Lynn A., De Jonge, Christopher J., Prins, Gail S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760152/ https://www.ncbi.nlm.nih.gov/pubmed/34542939 http://dx.doi.org/10.1111/andr.13110

Ejemplares similares

Polyphenylene carboxymethylene (PPCM), the active component of the topical contraceptive Yaso-GEL, exhibits potent antimicrobial activity against Neisseria gonorrhoeae in preclinical studies
por: Pilligua-Lucas, Michelle, et al.
Publicado: (2023)

Feasibility of Repurposing the Polyanionic Microbicide, PPCM, for Prophylaxis against HIV Transmission during ART
por: Anderson, Robert A., et al.
Publicado: (2011)

EnSNAREd by the Sperm Acrosome
Publicado: (2005)

Analysis of Clinical Profiles and Echocardiographic Cardiac Outcomes in Peripartum Cardiomyopathy (PPCM) vs. PPCM with Co-Existing Hypertensive Pregnancy Disorder (HPD-PPCM) Patients: A Systematic Review and Meta-Analysis
por: Nugrahani, Annisa Dewi, et al.
Publicado: (2023)

Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction
por: Naz, Rajesh K, et al.
Publicado: (2004)

Acrosomal reaction of Thyone sperm. II. The kinetics and possible mechanism of acrosomal process elongation
Publicado: (1982)

Sperm Nuclear Vacuoles in relation to Acrosome Reactions and Sperm Motility
por: Komiya, Akira, et al.
Publicado: (2014)

The Autophagy Marker LC3 Is Processed during the Sperm Capacitation and the Acrosome Reaction and Translocates to the Acrosome Where It Colocalizes with the Acrosomal Membranes in Horse Spermatozoa
por: Aparicio, Ines M., et al.
Publicado: (2023)

Discrete Dynamic Model of the Mammalian Sperm Acrosome Reaction: The Influence of Acrosomal pH and Physiological Heterogeneity
por: Aldana, Andrés, et al.
Publicado: (2021)

A genetically targeted sensor reveals spatial and temporal dynamics of acrosomal calcium and sperm acrosome exocytosis
por: Cohen, Roy, et al.
Publicado: (2022)

ACROSOMAL DISRUPTION IN SPERM : Freeze-Fracture of Altered Membranes
por: Friend, Daniel S., et al.
Publicado: (1974)

Prognostic value of NT-proBNP for myocardial recovery in peripartum cardiomyopathy (PPCM)
por: Hoevelmann, J., et al.
Publicado: (2021)

Is it necessary to focus on morphologically normal acrosome of sperm during intracytoplasmic sperm injection?
por: Zahiri, Ziba, et al.
Publicado: (2019)

Relationship of sperm plasma membrane and acrosomal integrities with sperm morphometry in Bos taurus
por: Palacín, Inmaculada, et al.
Publicado: (2020)

PPCM: Combing Multiple Classifiers to Improve Protein-Protein Interaction Prediction
por: Yao, Jianzhuang, et al.
Publicado: (2015)

Dynamics of SNARE Assembly and Disassembly during Sperm Acrosomal Exocytosis
por: Blas, Gerardo A. De, et al.
Publicado: (2005)

Redistribution of mouse sperm surface galactosyltransferase after the acrosome reaction
Publicado: (1987)

Acrosomal reaction of the Thyone sperm. III. The relationship between actin assembly and water influx during the extension of the acrosomal process
Publicado: (1985)

Incidence, Risk Factors, Maternal and Neonatal Outcomes of Peripartum Cardiomyopathy (PPCM) in Oman
por: Al Riyami, Nihal, et al.
Publicado: (2023)

Remodeling of the plasma membrane in preparation for sperm–egg recognition: roles of acrosomal proteins
por: Tanphaichitr, Nongnuj, et al.
Publicado: (2015)

Nitric oxide involvement in the acrosome reaction triggered by leptin in pig sperm
por: Aquila, Saveria, et al.
Publicado: (2011)

Regulation of sperm capacitation and the acrosome reaction by PIP(2) and actin modulation
por: Breitbart, Haim, et al.
Publicado: (2015)

Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry
por: Jackson, Alice M., et al.
Publicado: (2021)

The Use of Anti-VDAC2 Antibody for the Combined Assessment of Human Sperm Acrosome Integrity and Ionophore A23187-Induced Acrosome Reaction
por: Liu, Bianjiang, et al.
Publicado: (2011)

Acrosomal reaction of thyone sperm. I. Changes in the sperm head visualized by high resolution video microscopy
Publicado: (1982)

Presence and Function of Dopamine Transporter (DAT) in Stallion Sperm: Dopamine Modulates Sperm Motility and Acrosomal Integrity
por: Urra, Javier A., et al.
Publicado: (2014)

Regulatory mechanisms of the acrosome reaction revealed by multiview microscopy of single starfish sperm
Publicado: (1995)

Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction
Publicado: (1989)

THE POLYMERIZATION OF ACTIN: ITS ROLE IN THE GENERATION OF THE ACROSOMAL PROCESS OF CERTAIN ECHINODERM SPERM
por: Tilney, Lewis G., et al.
Publicado: (1973)

Characterization of a monoclonal antibody that induces the acrosome reaction of sea urchin sperm
Publicado: (1987)

The acrosomal membrane of boar sperm: a Golgi-derived membrane poor in glycoconjugates
Publicado: (1985)

How Pig Sperm Prepares to Fertilize: Stable Acrosome Docking to the Plasma Membrane
por: Tsai, Pei-Shiue, et al.
Publicado: (2010)

Silymarin protects plasma membrane and acrosome integrity in sperm treated with sodium arsenite
por: Eskandari, Farzaneh, et al.
Publicado: (2016)

A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome
por: Bhattacharya, Rupa, et al.
Publicado: (2013)

Effect of oviduct and follicular fluids on ram sperm capacitation and acrosome reaction in vitro
por: El-Shahat, K.H., et al.
Publicado: (2018)

Sugars Require Rigid Multivalent Displays for Activation of Mouse Sperm Acrosomal Exocytosis
por: Huang, He, et al.
Publicado: (2017)

Proteomic Changes in Human Sperm During Sequential in vitro Capacitation and Acrosome Reaction
por: Castillo, Judit, et al.
Publicado: (2019)

Exogenous gamma‐aminobutyric acid addition enhances porcine sperm acrosome reaction
por: Kurata, Shouhei, et al.
Publicado: (2022)

Electrocardiographic features and their echocardiographic correlates in peripartum cardiomyopathy: results from the ESC EORP PPCM registry
por: Mbakwem, Amam C., et al.
Publicado: (2021)

The Effect of Low-Level Laser Irradiation on Sperm Motility, and Integrity of the Plasma Membrane and Acrosome in Cryopreserved Bovine Sperm
por: Fernandes, Guilherme Henrique C., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_j4j6eae9h7qqklll2r45lgqd8p