Cargando…

Revisional Therapy for Recurrent Symptoms After Heller Myotomy for Achalasia

PURPOSE: Symptom recurrence after initial surgical management of esophageal achalasia occurs in 10–25% of patients. The aim of this study was to analyze safety and efficacy of revisional therapy after failed Heller myotomy (HM). METHODS: A retrospective review of a prospective database was performed...

Descripción completa

Detalles Bibliográficos
Autores principales: Milito, Pamela, Siboni, Stefano, Lovece, Andrea, Andreatta, Erika, Asti, Emanuele, Bonavina, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760227/
https://www.ncbi.nlm.nih.gov/pubmed/34341888
http://dx.doi.org/10.1007/s11605-021-05098-8
_version_ 1784633271161716736
author Milito, Pamela
Siboni, Stefano
Lovece, Andrea
Andreatta, Erika
Asti, Emanuele
Bonavina, Luigi
author_facet Milito, Pamela
Siboni, Stefano
Lovece, Andrea
Andreatta, Erika
Asti, Emanuele
Bonavina, Luigi
author_sort Milito, Pamela
collection PubMed
description PURPOSE: Symptom recurrence after initial surgical management of esophageal achalasia occurs in 10–25% of patients. The aim of this study was to analyze safety and efficacy of revisional therapy after failed Heller myotomy (HM). METHODS: A retrospective review of a prospective database was performed searching for patients with recurrent symptoms after primary surgical therapy for achalasia. Patients with previously failed HM were considered for the final analysis. The Foregut questionnaire, and the Atkinson and Eckardt scales were used to assess severity of symptoms. Objective investigations routinely included upper gastrointestinal endoscopy and barium swallow study. Redo treatments consisted of endoscopic pneumatic dilation (PD), laparoscopic HM, hybrid Ivor Lewis esophagectomy, or stapled cardioplasty. A yearly clinical and endoscopic follow-up was scheduled in all patients. RESULTS: Over a 20-year period, 26 patients with a median age of 66 years (IQR 19.5) underwent revisional therapy after failed HM for achalasia at a tertiary-care university hospital. The median time after index procedure was 10 years (IQR 21). Revisional therapy consisted of endoscopic pneumatic dilation (n=13), laparoscopic HM and fundoplication (n=10), esophagectomy (n=2), and stapled cardioplasty and fundoplication (n=1). Nine (34.6%) of these patients required further endoscopic or surgical treatments. There was no mortality, and the overall complication rate was 7.7%. At a median follow-up of 42 months (range 10–149), a significant decrease of dysphagia, regurgitation, chest pain, respiratory symptoms, and median Eckardt score (p<0.05) was noted. CONCLUSION: In specialized and multidisciplinary centers, revisional therapy for achalasia is feasible, safe, and effective.
format Online
Article
Text
id pubmed-8760227
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-87602272022-01-26 Revisional Therapy for Recurrent Symptoms After Heller Myotomy for Achalasia Milito, Pamela Siboni, Stefano Lovece, Andrea Andreatta, Erika Asti, Emanuele Bonavina, Luigi J Gastrointest Surg Original Article PURPOSE: Symptom recurrence after initial surgical management of esophageal achalasia occurs in 10–25% of patients. The aim of this study was to analyze safety and efficacy of revisional therapy after failed Heller myotomy (HM). METHODS: A retrospective review of a prospective database was performed searching for patients with recurrent symptoms after primary surgical therapy for achalasia. Patients with previously failed HM were considered for the final analysis. The Foregut questionnaire, and the Atkinson and Eckardt scales were used to assess severity of symptoms. Objective investigations routinely included upper gastrointestinal endoscopy and barium swallow study. Redo treatments consisted of endoscopic pneumatic dilation (PD), laparoscopic HM, hybrid Ivor Lewis esophagectomy, or stapled cardioplasty. A yearly clinical and endoscopic follow-up was scheduled in all patients. RESULTS: Over a 20-year period, 26 patients with a median age of 66 years (IQR 19.5) underwent revisional therapy after failed HM for achalasia at a tertiary-care university hospital. The median time after index procedure was 10 years (IQR 21). Revisional therapy consisted of endoscopic pneumatic dilation (n=13), laparoscopic HM and fundoplication (n=10), esophagectomy (n=2), and stapled cardioplasty and fundoplication (n=1). Nine (34.6%) of these patients required further endoscopic or surgical treatments. There was no mortality, and the overall complication rate was 7.7%. At a median follow-up of 42 months (range 10–149), a significant decrease of dysphagia, regurgitation, chest pain, respiratory symptoms, and median Eckardt score (p<0.05) was noted. CONCLUSION: In specialized and multidisciplinary centers, revisional therapy for achalasia is feasible, safe, and effective. Springer US 2021-08-02 2022 /pmc/articles/PMC8760227/ /pubmed/34341888 http://dx.doi.org/10.1007/s11605-021-05098-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Milito, Pamela
Siboni, Stefano
Lovece, Andrea
Andreatta, Erika
Asti, Emanuele
Bonavina, Luigi
Revisional Therapy for Recurrent Symptoms After Heller Myotomy for Achalasia
title Revisional Therapy for Recurrent Symptoms After Heller Myotomy for Achalasia
title_full Revisional Therapy for Recurrent Symptoms After Heller Myotomy for Achalasia
title_fullStr Revisional Therapy for Recurrent Symptoms After Heller Myotomy for Achalasia
title_full_unstemmed Revisional Therapy for Recurrent Symptoms After Heller Myotomy for Achalasia
title_short Revisional Therapy for Recurrent Symptoms After Heller Myotomy for Achalasia
title_sort revisional therapy for recurrent symptoms after heller myotomy for achalasia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760227/
https://www.ncbi.nlm.nih.gov/pubmed/34341888
http://dx.doi.org/10.1007/s11605-021-05098-8
work_keys_str_mv AT militopamela revisionaltherapyforrecurrentsymptomsafterhellermyotomyforachalasia
AT sibonistefano revisionaltherapyforrecurrentsymptomsafterhellermyotomyforachalasia
AT loveceandrea revisionaltherapyforrecurrentsymptomsafterhellermyotomyforachalasia
AT andreattaerika revisionaltherapyforrecurrentsymptomsafterhellermyotomyforachalasia
AT astiemanuele revisionaltherapyforrecurrentsymptomsafterhellermyotomyforachalasia
AT bonavinaluigi revisionaltherapyforrecurrentsymptomsafterhellermyotomyforachalasia