HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that acts as a regulator of oxygen (O(2)) homeostasis in metazoan species by binding to hypoxia response elements (HREs) and activating the transcription of hundreds of genes in response to reduced O(2) availability. RNA polymerase II (Pol...

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Detalles Bibliográficos
Autores principales: Yang, Yongkang, Lu, Haiquan, Chen, Chelsey, Lyu, Yajing, Cole, Robert N., Semenza, Gregg L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760265/
https://www.ncbi.nlm.nih.gov/pubmed/35031618
http://dx.doi.org/10.1038/s41467-021-27944-8

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