Cargando…

Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice

The lung is one of the most sensitive tissues to ionizing radiation, thus, radiation-induced lung injury (RILI) stays a key dose-limiting factor of thoracic radiotherapy. However, there is still little progress in the effective treatment of RILI. Ras-related C3 botulinum toxin substrate1, Rac1, is a...

Descripción completa

Detalles Bibliográficos
Autores principales:	An, Ni, Li, Zhenjie, Yan, Xiaodi, Zhao, Hainan, Yang, Yajie, Liu, Ruling, Yang, Yanyong, Gao, Fu, Li, Bailong, Liu, Hu, Yuan, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760284/ https://www.ncbi.nlm.nih.gov/pubmed/35031595 http://dx.doi.org/10.1038/s41420-021-00791-8

Ejemplares similares

Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury
por: Huang, Yijuan, et al.
Publicado: (2014)

Polydatin alleviated radiation‐induced lung injury through activation of Sirt3 and inhibition of epithelial–mesenchymal transition
por: Cao, Kun, et al.
Publicado: (2017)

Polydatin radiosensitizes lung cancer while preventing radiation injuries by modulating tumor-infiltrating B cells
por: Guo, Jiaming, et al.
Publicado: (2023)

Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway
por: Xu, Yang, et al.
Publicado: (2021)

Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition – More Than Just ROS-inhibition
por: Sha, Zhilin, et al.
Publicado: (2022)

Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice
por: Guo, Jiaming, et al.
Publicado: (2016)

Effects of (12)C(6+) Heavy Ion Radiation on Dendritic Cells Function
por: Zhang, Pei, et al.
Publicado: (2018)

Analysis of miRNA-mRNA Crosstalk in Radiation-Induced Mouse Thymic Lymphomas to Identify miR-486 as a Critical Regulator by Targeting IGF2BP3 mRNA
por: Zhao, Hainan, et al.
Publicado: (2021)

Glibenclamide, a diabetic drug, prevents acute radiation-induced liver injury of mice via up-regulating intracellular ROS and subsequently activating Akt–NF-κB pathway
por: Liu, Hu, et al.
Publicado: (2017)

Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo
por: Huang, Yijuan, et al.
Publicado: (2016)

Radioprotective effects of roxadustat (FG‐4592) in haematopoietic system
por: Zhang, Pei, et al.
Publicado: (2018)

Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation
por: Qu, Hongjin, et al.
Publicado: (2019)

Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis
por: Yang, Yanyong, et al.
Publicado: (2012)

Sirt3 Promoted DNA Damage Repair and Radioresistance Through ATM-Chk2 in Non-small Cell Lung Cancer Cells
por: Cao, Kun, et al.
Publicado: (2021)

Monophosphoryl lipid a attenuates radiation injury through TLR4 activation
por: Guo, Jiaming, et al.
Publicado: (2017)

TLR4 Agonist Monophosphoryl Lipid A Alleviated Radiation-Induced Intestinal Injury
por: Guo, Jiaming, et al.
Publicado: (2019)

Heat-killed salmonella typhimurium (HKST) protects mice against radiation in TLR4-dependent manner
por: Xu, Yang, et al.
Publicado: (2017)

Rac-GEF/Rac Signaling and Metastatic Dissemination in Lung Cancer
por: Cooke, Mariana, et al.
Publicado: (2020)

Migrasome: a new functional extracellular vesicle
por: Zhang, Xide, et al.
Publicado: (2023)

Heat Killed Salmonella typhimurium Protects Intestine Against Radiation Injury Through Wnt Signaling Pathway
por: Chen, Yuanyuan, et al.
Publicado: (2021)

Azithromycin attenuates acute radiation-induced lung injury in mice
por: Tang, Fei, et al.
Publicado: (2017)

Gamma-ray Irradiation Impairs Dendritic Cell Migration to CCL19 by Down-regulation of CCR7 and Induction of Cell Apoptosis
por: Liu, Cong, et al.
Publicado: (2011)

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
por: Zhou, Chun, et al.
Publicado: (2012)

Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury
por: Ismaiel, Nada, et al.
Publicado: (2022)

Combined BRM270 and endostatin inhibit relapse of NSCLC while suppressing lung cancer stem cell proliferation induced by endostatin
por: Gu, Yan-hui, et al.
Publicado: (2021)

Protective effects of activated vitamin D receptor on radiation‐induced intestinal injury
por: Lin, Yuhan, et al.
Publicado: (2022)

Endothelial Rac1 is essential for hematogenous metastasis to the lung
por: Yao, Hongyi, et al.
Publicado: (2015)

DAL-1 attenuates epithelial-to mesenchymal transition in lung cancer
por: Chen, Xianliang, et al.
Publicado: (2015)

MiR-34a in Age and Tissue Related Radio-Sensitivity and Serum miR-34a as a Novel Indicator of Radiation Injury
por: Liu, Cong, et al.
Publicado: (2011)

Tetramethylpyrazine ameliorates acute lung injury by regulating the Rac1/LIMK1 signaling pathway
por: Min, Simin, et al.
Publicado: (2023)

Identification of RAC1 in promoting brain metastasis of lung adenocarcinoma using single-cell transcriptome sequencing
por: Chen, Mingyu, et al.
Publicado: (2023)

Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice
por: Lee, Seung Jun, et al.
Publicado: (2015)

Rac1 Targeting Suppresses Human Non-Small Cell Lung Adenocarcinoma Cancer Stem Cell Activity
por: Akunuru, Shailaja, et al.
Publicado: (2011)

MNK as a potential pharmacological target for suppressing LPS-induced acute lung injury in mice
por: Gao, Jianfeng, et al.
Publicado: (2021)

TIPE2 suppresses angiogenesis and non-small cell lung cancer (NSCLC) invasiveness via inhibiting Rac1 activation and VEGF expression
por: Li, Zequn, et al.
Publicado: (2016)

Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway
por: Li, Li-Fu, et al.
Publicado: (2017)

Pharmacological targeting of BET proteins attenuates radiation-induced lung fibrosis
por: Wang, Jian, et al.
Publicado: (2018)

Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance
por: Liu, Lei, et al.
Publicado: (2021)

Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs
por: Cho, Yu Ji, et al.
Publicado: (2013)

Attenuation of Radiation-Induced Lung Injury by Hyaluronic Acid Nanoparticles
por: Lierova, Anna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r5oieqhcdnj2rc6fr032r2rrv2