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Serious role of non-quarantined COVID-19 patients for random walk simulations

The infectious disease (COVID-19) causes serious damages and outbreaks. A large number of infected people have been reported in the world. However, such a number only represents those who have been tested; e.g. PCR test. We focus on the infected individuals who are not checked by inspections. The su...

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Autores principales: Nakagiri, Nariyuki, Sato, Kazunori, Sakisaka, Yukio, Tainaka, Kei-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760292/
https://www.ncbi.nlm.nih.gov/pubmed/35031645
http://dx.doi.org/10.1038/s41598-021-04629-2
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author Nakagiri, Nariyuki
Sato, Kazunori
Sakisaka, Yukio
Tainaka, Kei-ichi
author_facet Nakagiri, Nariyuki
Sato, Kazunori
Sakisaka, Yukio
Tainaka, Kei-ichi
author_sort Nakagiri, Nariyuki
collection PubMed
description The infectious disease (COVID-19) causes serious damages and outbreaks. A large number of infected people have been reported in the world. However, such a number only represents those who have been tested; e.g. PCR test. We focus on the infected individuals who are not checked by inspections. The susceptible-infected-recovered (SIR) model is modified: infected people are divided into quarantined (Q) and non-quarantined (N) agents. Since N-agents behave like uninfected people, they can move around in a stochastic simulation. Both theory of well-mixed population and simulation of random-walk reveal that the total population size of Q-agents decrease in spite of increasing the number of tests. Such a paradox appears, when the ratio of Q exceeds a critical value. Random-walk simulations indicate that the infection hardly spreads, if the movement of all people is prohibited ("lockdown"). In this case the infected people are clustered and locally distributed within narrow spots. The similar result can be obtained, even when only non-infected people move around. However, when both N-agents and uninfected people move around, the infection spreads everywhere. Hence, it may be important to promote the inspections even for asymptomatic people, because most of N-agents are mild or asymptomatic.
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spelling pubmed-87602922022-01-18 Serious role of non-quarantined COVID-19 patients for random walk simulations Nakagiri, Nariyuki Sato, Kazunori Sakisaka, Yukio Tainaka, Kei-ichi Sci Rep Article The infectious disease (COVID-19) causes serious damages and outbreaks. A large number of infected people have been reported in the world. However, such a number only represents those who have been tested; e.g. PCR test. We focus on the infected individuals who are not checked by inspections. The susceptible-infected-recovered (SIR) model is modified: infected people are divided into quarantined (Q) and non-quarantined (N) agents. Since N-agents behave like uninfected people, they can move around in a stochastic simulation. Both theory of well-mixed population and simulation of random-walk reveal that the total population size of Q-agents decrease in spite of increasing the number of tests. Such a paradox appears, when the ratio of Q exceeds a critical value. Random-walk simulations indicate that the infection hardly spreads, if the movement of all people is prohibited ("lockdown"). In this case the infected people are clustered and locally distributed within narrow spots. The similar result can be obtained, even when only non-infected people move around. However, when both N-agents and uninfected people move around, the infection spreads everywhere. Hence, it may be important to promote the inspections even for asymptomatic people, because most of N-agents are mild or asymptomatic. Nature Publishing Group UK 2022-01-14 /pmc/articles/PMC8760292/ /pubmed/35031645 http://dx.doi.org/10.1038/s41598-021-04629-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nakagiri, Nariyuki
Sato, Kazunori
Sakisaka, Yukio
Tainaka, Kei-ichi
Serious role of non-quarantined COVID-19 patients for random walk simulations
title Serious role of non-quarantined COVID-19 patients for random walk simulations
title_full Serious role of non-quarantined COVID-19 patients for random walk simulations
title_fullStr Serious role of non-quarantined COVID-19 patients for random walk simulations
title_full_unstemmed Serious role of non-quarantined COVID-19 patients for random walk simulations
title_short Serious role of non-quarantined COVID-19 patients for random walk simulations
title_sort serious role of non-quarantined covid-19 patients for random walk simulations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760292/
https://www.ncbi.nlm.nih.gov/pubmed/35031645
http://dx.doi.org/10.1038/s41598-021-04629-2
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