Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin’s lymphoma characterized by poor prognosis. The complexity of MCL pathogenesis arises from aberrant activities of diverse signaling pathways, including BTK, PI3K–AKT–mTOR and MYC-BRD4. Here, we report that MCL-related signaling pathways can be a...

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Detalles Bibliográficos
Autores principales: Vann, Kendra R., Pal, Dhananjaya, Smith, Audrey L., Sahar, Namood-e, Krishnaiah, Maddeboina, El-Gamal, Dalia, Kutateladze, Tatiana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760370/
https://www.ncbi.nlm.nih.gov/pubmed/35031886
http://dx.doi.org/10.1186/s43556-021-00066-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760370/
https://www.ncbi.nlm.nih.gov/pubmed/35031886
http://dx.doi.org/10.1186/s43556-021-00066-9

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