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Risk factors for actinic cheilitis: A meta-analysis

Background. Actinic cheilitis (AC) is a potentially malignant disorder characterized by chronic lip inflammation, especially the lower lip, associated with accumulative exposure to solar radiation. The present study aimed to assess the possible risk factors related to AC. Methods. A search for studi...

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Autores principales: Rodriguez-Archilla, Alberto, Irfan-Bhatti, Amna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760378/
https://www.ncbi.nlm.nih.gov/pubmed/35070184
http://dx.doi.org/10.34172/joddd.2021.047
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author Rodriguez-Archilla, Alberto
Irfan-Bhatti, Amna
author_facet Rodriguez-Archilla, Alberto
Irfan-Bhatti, Amna
author_sort Rodriguez-Archilla, Alberto
collection PubMed
description Background. Actinic cheilitis (AC) is a potentially malignant disorder characterized by chronic lip inflammation, especially the lower lip, associated with accumulative exposure to solar radiation. The present study aimed to assess the possible risk factors related to AC. Methods. A search for studies on AC risk factors was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Google Scholar. For dichotomous outcomes, the estimates of the effects of intervention were expressed as odds ratios (ORs) using Mantel-Haenszel (M-H) method, and for continuous outcomes, the estimates of the effects of intervention were expressed as mean difference (MD) using the inverse variance (IV) method, both with 95% confidence intervals. Results. Twelve studies were considered in this meta-analysis. The factors from the highest to lowest risk of AC were having a low skin phototype (OR: 3.30), age >50 years (OR: 3.01), having high sun exposure, cumulative throughout life (OR: 2.13) as daily (OR: 2.00), being male (OR: 1.78), and being a drinker (OR: 1.56) or smoker (OR: 1.32). However, the use of sunscreen creams and caps/hats to protect against the sun were factors with no significant influence on the AC risk. Conclusion. Chronic sun exposure in subjects with low skin phototypes is the main risk factor for AC.
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spelling pubmed-87603782022-01-21 Risk factors for actinic cheilitis: A meta-analysis Rodriguez-Archilla, Alberto Irfan-Bhatti, Amna J Dent Res Dent Clin Dent Prospects Meta Analysis Background. Actinic cheilitis (AC) is a potentially malignant disorder characterized by chronic lip inflammation, especially the lower lip, associated with accumulative exposure to solar radiation. The present study aimed to assess the possible risk factors related to AC. Methods. A search for studies on AC risk factors was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Google Scholar. For dichotomous outcomes, the estimates of the effects of intervention were expressed as odds ratios (ORs) using Mantel-Haenszel (M-H) method, and for continuous outcomes, the estimates of the effects of intervention were expressed as mean difference (MD) using the inverse variance (IV) method, both with 95% confidence intervals. Results. Twelve studies were considered in this meta-analysis. The factors from the highest to lowest risk of AC were having a low skin phototype (OR: 3.30), age >50 years (OR: 3.01), having high sun exposure, cumulative throughout life (OR: 2.13) as daily (OR: 2.00), being male (OR: 1.78), and being a drinker (OR: 1.56) or smoker (OR: 1.32). However, the use of sunscreen creams and caps/hats to protect against the sun were factors with no significant influence on the AC risk. Conclusion. Chronic sun exposure in subjects with low skin phototypes is the main risk factor for AC. Tabriz University of Medical Sciences 2021 2021-12-05 /pmc/articles/PMC8760378/ /pubmed/35070184 http://dx.doi.org/10.34172/joddd.2021.047 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Meta Analysis
Rodriguez-Archilla, Alberto
Irfan-Bhatti, Amna
Risk factors for actinic cheilitis: A meta-analysis
title Risk factors for actinic cheilitis: A meta-analysis
title_full Risk factors for actinic cheilitis: A meta-analysis
title_fullStr Risk factors for actinic cheilitis: A meta-analysis
title_full_unstemmed Risk factors for actinic cheilitis: A meta-analysis
title_short Risk factors for actinic cheilitis: A meta-analysis
title_sort risk factors for actinic cheilitis: a meta-analysis
topic Meta Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760378/
https://www.ncbi.nlm.nih.gov/pubmed/35070184
http://dx.doi.org/10.34172/joddd.2021.047
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