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Small cell carcinoma of the ovary, pulmonary type: A role for adjuvant radiotherapy after carboplatin and etoposide?

BACKGROUND: Primary small cell ovarian cancer of pulmonary type (SCCOPT) remains a rare ovarian tumor. Its aggressive nature is associated with poor survival outcomes. Current treatment algorithms rely on systemic chemotherapy, primarily involving platinum agents. However, given its low incidence, l...

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Autores principales: Asom, Anase S., Lastra, Ricardo R., Hasan, Yasmin, Weinberg, Lori, Fleming, Gini F., Kurnit, Katherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760400/
https://www.ncbi.nlm.nih.gov/pubmed/35059489
http://dx.doi.org/10.1016/j.gore.2022.100925
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author Asom, Anase S.
Lastra, Ricardo R.
Hasan, Yasmin
Weinberg, Lori
Fleming, Gini F.
Kurnit, Katherine C.
author_facet Asom, Anase S.
Lastra, Ricardo R.
Hasan, Yasmin
Weinberg, Lori
Fleming, Gini F.
Kurnit, Katherine C.
author_sort Asom, Anase S.
collection PubMed
description BACKGROUND: Primary small cell ovarian cancer of pulmonary type (SCCOPT) remains a rare ovarian tumor. Its aggressive nature is associated with poor survival outcomes. Current treatment algorithms rely on systemic chemotherapy, primarily involving platinum agents. However, given its low incidence, less is known about the potential benefits of other treatments. CASE PRESENTATION: We report a case of an 80-year-old woman who was found to have a complex pelvic mass with a mildly elevated CA-125. She underwent a laparotomy for staging with tumor debulking; she had bulky unresectable adenopathy and pathology was consistent with stage IIIC SCCOPT. Postoperative imaging revealed progression of disease. She received six cycles of carboplatin and etoposide followed by consolidative radiation therapy to her para-aortic lymph nodes. She remains disease-free for over four years after completion of adjuvant therapy. DISCUSSION: Histologically, SCCOPT resembles small cell carcinomas of the lung, which are treated with a combination of chemotherapy and radiation therapy. New approaches that build upon the current treatment approaches and incorporate strategies from non-gynecologic tumor types could be beneficial.
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spelling pubmed-87604002022-01-19 Small cell carcinoma of the ovary, pulmonary type: A role for adjuvant radiotherapy after carboplatin and etoposide? Asom, Anase S. Lastra, Ricardo R. Hasan, Yasmin Weinberg, Lori Fleming, Gini F. Kurnit, Katherine C. Gynecol Oncol Rep Case Report BACKGROUND: Primary small cell ovarian cancer of pulmonary type (SCCOPT) remains a rare ovarian tumor. Its aggressive nature is associated with poor survival outcomes. Current treatment algorithms rely on systemic chemotherapy, primarily involving platinum agents. However, given its low incidence, less is known about the potential benefits of other treatments. CASE PRESENTATION: We report a case of an 80-year-old woman who was found to have a complex pelvic mass with a mildly elevated CA-125. She underwent a laparotomy for staging with tumor debulking; she had bulky unresectable adenopathy and pathology was consistent with stage IIIC SCCOPT. Postoperative imaging revealed progression of disease. She received six cycles of carboplatin and etoposide followed by consolidative radiation therapy to her para-aortic lymph nodes. She remains disease-free for over four years after completion of adjuvant therapy. DISCUSSION: Histologically, SCCOPT resembles small cell carcinomas of the lung, which are treated with a combination of chemotherapy and radiation therapy. New approaches that build upon the current treatment approaches and incorporate strategies from non-gynecologic tumor types could be beneficial. Elsevier 2022-01-07 /pmc/articles/PMC8760400/ /pubmed/35059489 http://dx.doi.org/10.1016/j.gore.2022.100925 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Asom, Anase S.
Lastra, Ricardo R.
Hasan, Yasmin
Weinberg, Lori
Fleming, Gini F.
Kurnit, Katherine C.
Small cell carcinoma of the ovary, pulmonary type: A role for adjuvant radiotherapy after carboplatin and etoposide?
title Small cell carcinoma of the ovary, pulmonary type: A role for adjuvant radiotherapy after carboplatin and etoposide?
title_full Small cell carcinoma of the ovary, pulmonary type: A role for adjuvant radiotherapy after carboplatin and etoposide?
title_fullStr Small cell carcinoma of the ovary, pulmonary type: A role for adjuvant radiotherapy after carboplatin and etoposide?
title_full_unstemmed Small cell carcinoma of the ovary, pulmonary type: A role for adjuvant radiotherapy after carboplatin and etoposide?
title_short Small cell carcinoma of the ovary, pulmonary type: A role for adjuvant radiotherapy after carboplatin and etoposide?
title_sort small cell carcinoma of the ovary, pulmonary type: a role for adjuvant radiotherapy after carboplatin and etoposide?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760400/
https://www.ncbi.nlm.nih.gov/pubmed/35059489
http://dx.doi.org/10.1016/j.gore.2022.100925
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