Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells

Disturbance of the dynamic balance between tyrosine phosphorylation and dephosphorylation of signaling molecules, controlled by protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is known to lead to the development of cancer. While most approved targeted cancer therapies are tyrosine...

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Detalles Bibliográficos
Autores principales: Raveendra-Panickar, Dhanya, Finlay, Darren, Layng, Fabiana Izidro, Lambert, Lester J., Celeridad, Maria, Zhao, Ming, Barbosa, Karina, De Backer, Laurent J.S., Kwong, Elizabeth, Gosalia, Palak, Rodiles, Socorro, Holleran, John, Ardecky, Robert, Grotegut, Stefan, Olson, Steven, Hutchinson, John H., Pasquale, Elena B., Vuori, Kristiina, Deshpande, Aniruddha J., Cosford, Nicholas D.P., Tautz, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760490/
https://www.ncbi.nlm.nih.gov/pubmed/34896393
http://dx.doi.org/10.1016/j.jbc.2021.101477

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