Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination

Resistance to the last-line polymyxins is emerging in multidrug-resistant Klebsiella pneumoniae and phage therapy is a promising alternative. However, phage monotherapy often rapidly causes resistance and few studies have examined antibiotic-phage combinations against K. pneumoniae. Here, we investi...

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Detalles Bibliográficos
Autores principales: Han, Mei-Ling, Nang, Sue C., Lin, Yu-Wei, Zhu, Yan, Yu, Heidi H., Wickremasinghe, Hasini, Barlow, Christopher K., Creek, Darren J., Crawford, Simon, Rao, Gauri, Dai, Chongshan, Barr, Jeremy J., Chan, Kim, Turner Schooley, Robert, Velkov, Tony, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760530/
https://www.ncbi.nlm.nih.gov/pubmed/35070170
http://dx.doi.org/10.1016/j.csbj.2021.12.039

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