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Identification of a dihydropyridine scaffold that blocks ryanodine receptors

Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca(2+) release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies, arrhythmia, heart failure, and Alzheimer's disease. Th...

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Detalles Bibliográficos
Autores principales:	Gunaratne, Gihan S., Rebbeck, Robyn T., McGurran, Lindsey M., Yan, Yasheng, Arzua, Thiago, Frolkis, Talia, Sprague, Daniel J., Bai, Xiaowen, Cornea, Razvan L., Walseth, Timothy F., Marchant, Jonathan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760560/ https://www.ncbi.nlm.nih.gov/pubmed/35059610 http://dx.doi.org/10.1016/j.isci.2021.103706

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