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A Pig-a conditional knock-out mice model mediated by Vav-iCre: stable GPI-deficient and mild hemolysis

Paroxysmal nocturnal hemoglobinuria is a clonal disease caused by PIG-A mutation of hematopoietic stem cells. At present, there is no suitable PNH animal model for basic research, therefore, it is urgent to establish a stable animal model. We constructed a Pig-a conditional knock-out mice model by E...

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Detalles Bibliográficos
Autores principales:	Chen, Yingying, Liu, Hui, Zeng, Lijie, Li, Liyan, Lu, Dan, Liu, Zhaoyun, Fu, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760646/ https://www.ncbi.nlm.nih.gov/pubmed/35033195 http://dx.doi.org/10.1186/s40164-022-00254-5

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