Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells

Although some variation introgressed from Neanderthals has undergone selective sweeps, little is known about its functional significance. We used a Massively Parallel Reporter Assay (MPRA) to assay 5,353 high-frequency introgressed variants for their ability to modulate the gene expression within 17...

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Detalles Bibliográficos
Autores principales: Jagoda, Evelyn, Xue, James R, Reilly, Steven K, Dannemann, Michael, Racimo, Fernando, Huerta-Sanchez, Emilia, Sankararaman, Sriram, Kelso, Janet, Pagani, Luca, Sabeti, Pardis C, Capellini, Terence D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760939/
https://www.ncbi.nlm.nih.gov/pubmed/34662402
http://dx.doi.org/10.1093/molbev/msab304

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