Humanization of antibodies using a machine learning approach on large-scale repertoire data

MOTIVATION: Monoclonal antibody (mAb) therapeutics are often produced from non-human sources (typically murine), and can therefore generate immunogenic responses in humans. Humanization procedures aim to produce antibody therapeutics that do not elicit an immune response and are safe for human use,...

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Detalles Bibliográficos
Autores principales: Marks, Claire, Hummer, Alissa M, Chin, Mark, Deane, Charlotte M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760955/
https://www.ncbi.nlm.nih.gov/pubmed/34110413
http://dx.doi.org/10.1093/bioinformatics/btab434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760955/
https://www.ncbi.nlm.nih.gov/pubmed/34110413
http://dx.doi.org/10.1093/bioinformatics/btab434

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