Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice

Systemic deletion of senescent cells leads to robust improvements in cognitive, cardiovascular, and whole‐body metabolism, but their role in tissue reparative processes is incompletely understood. We hypothesized that senolytic drugs would enhance regeneration in aged skeletal muscle. Young (3 month...

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Detalles Bibliográficos
Autores principales: Dungan, Cory M., Murach, Kevin A., Zdunek, Christopher J., Tang, Zuo Jian, Nolt, Georgia L., Brightwell, Camille R., Hettinger, Zachary, Englund, Davis A., Liu, Zheng, Fry, Christopher S., Filareto, Antonio, Franti, Michael, Peterson, Charlotte A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761017/
https://www.ncbi.nlm.nih.gov/pubmed/34904366
http://dx.doi.org/10.1111/acel.13528

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