Ins and outs of AlphaFold2 transmembrane protein structure predictions

Transmembrane (TM) proteins are major drug targets, but their structure determination, a prerequisite for rational drug design, remains challenging. Recently, the DeepMind’s AlphaFold2 machine learning method greatly expanded the structural coverage of sequences with high accuracy. Since the employe...

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Detalles Bibliográficos
Autores principales: Hegedűs, Tamás, Geisler, Markus, Lukács, Gergely László, Farkas, Bianka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761152/
https://www.ncbi.nlm.nih.gov/pubmed/35034173
http://dx.doi.org/10.1007/s00018-021-04112-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761152/
https://www.ncbi.nlm.nih.gov/pubmed/35034173
http://dx.doi.org/10.1007/s00018-021-04112-1

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