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Therapeutic targeting of ARID1A and PI3K/AKT pathway alterations in cholangiocarcinoma

BACKGROUND: Genetic alterations in ARID1A were detected at a high frequency in cholangiocarcinoma (CCA). Growing evidence indicates that the loss of ARID1A expression leads to activation of the PI3K/AKT pathway and increasing sensitivity of ARID1A-deficient cells for treatment with the PI3K/AKT inhi...

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Detalles Bibliográficos
Autores principales:	Tessiri, Supharada, Techasen, Anchalee, Kongpetch, Sarinya, Namjan, Achira, Loilome, Watcharin, Chan-on, Waraporn, Thanan, Raynoo, Jusakul, Apinya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2022
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761367/ https://www.ncbi.nlm.nih.gov/pubmed/35070505 http://dx.doi.org/10.7717/peerj.12750

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