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Association between serum hemoglobin and major cardiovascular adverse event in Chinese patients with ST‐segment elevation myocardial infarction after percutaneous coronary intervention

BACKGROUND: ST‐segment elevation myocardial infarction (STEMI) is a common clinical acute and severe disease, and it is of great significance to evaluate the prognosis of these patients. Hemoglobin levels are associated with a variety of diseases, but studies on Chinese patients with STEMI after per...

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Autores principales: Yang, Yulu, Huang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761445/
https://www.ncbi.nlm.nih.gov/pubmed/34894008
http://dx.doi.org/10.1002/jcla.24126
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author Yang, Yulu
Huang, Yun
author_facet Yang, Yulu
Huang, Yun
author_sort Yang, Yulu
collection PubMed
description BACKGROUND: ST‐segment elevation myocardial infarction (STEMI) is a common clinical acute and severe disease, and it is of great significance to evaluate the prognosis of these patients. Hemoglobin levels are associated with a variety of diseases, but studies on Chinese patients with STEMI after percutaneous coronary intervention (PCI) have not been sufficient. METHODS: This was a secondary analysis based on a prospective cohort study of patients undergoing PCI in Taizhou, Zhejiang, China. We performed multivariable logistic regression to explore the association between the serum hemoglobin and the incidence of major cardiovascular adverse event (MACE) in patients after PCI. We also used a generalized additive model and smooth curve fitting to explain the nonlinear relationship after adjusting the potential confounders. Finally, the heterogeneity among specific groups was examined by subgroup analysis. RESULTS: Of all 462 patients enrolled in this study, 118 (25.54%) developed MACE. There was a negative correlation between serum hemoglobin and MACE in all three models (hazard ratio [HR] 0.82, 95% confidence interval [CI 0.72, 0.93], HR 0.86, 95% CI [0.76,0.98], and HR 0.87, 95% CI [0.74,0.98], respectively). In the subgroup analysis, the negative correlation existed between the patients who had myocardial infarction (MI) history (p for interaction = 0.0059) after adjusting covariates. However, no significant differences were found between age and sex groups (p for interaction = 0.1381, 0.4103, respectively). CONCLUSION: Our results indicated that patients who received PCI with low preoperative hemoglobin were more likely to develop MACE, especially if they have already had a history of MI.
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spelling pubmed-87614452022-01-20 Association between serum hemoglobin and major cardiovascular adverse event in Chinese patients with ST‐segment elevation myocardial infarction after percutaneous coronary intervention Yang, Yulu Huang, Yun J Clin Lab Anal Research Articles BACKGROUND: ST‐segment elevation myocardial infarction (STEMI) is a common clinical acute and severe disease, and it is of great significance to evaluate the prognosis of these patients. Hemoglobin levels are associated with a variety of diseases, but studies on Chinese patients with STEMI after percutaneous coronary intervention (PCI) have not been sufficient. METHODS: This was a secondary analysis based on a prospective cohort study of patients undergoing PCI in Taizhou, Zhejiang, China. We performed multivariable logistic regression to explore the association between the serum hemoglobin and the incidence of major cardiovascular adverse event (MACE) in patients after PCI. We also used a generalized additive model and smooth curve fitting to explain the nonlinear relationship after adjusting the potential confounders. Finally, the heterogeneity among specific groups was examined by subgroup analysis. RESULTS: Of all 462 patients enrolled in this study, 118 (25.54%) developed MACE. There was a negative correlation between serum hemoglobin and MACE in all three models (hazard ratio [HR] 0.82, 95% confidence interval [CI 0.72, 0.93], HR 0.86, 95% CI [0.76,0.98], and HR 0.87, 95% CI [0.74,0.98], respectively). In the subgroup analysis, the negative correlation existed between the patients who had myocardial infarction (MI) history (p for interaction = 0.0059) after adjusting covariates. However, no significant differences were found between age and sex groups (p for interaction = 0.1381, 0.4103, respectively). CONCLUSION: Our results indicated that patients who received PCI with low preoperative hemoglobin were more likely to develop MACE, especially if they have already had a history of MI. John Wiley and Sons Inc. 2021-12-10 /pmc/articles/PMC8761445/ /pubmed/34894008 http://dx.doi.org/10.1002/jcla.24126 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Yang, Yulu
Huang, Yun
Association between serum hemoglobin and major cardiovascular adverse event in Chinese patients with ST‐segment elevation myocardial infarction after percutaneous coronary intervention
title Association between serum hemoglobin and major cardiovascular adverse event in Chinese patients with ST‐segment elevation myocardial infarction after percutaneous coronary intervention
title_full Association between serum hemoglobin and major cardiovascular adverse event in Chinese patients with ST‐segment elevation myocardial infarction after percutaneous coronary intervention
title_fullStr Association between serum hemoglobin and major cardiovascular adverse event in Chinese patients with ST‐segment elevation myocardial infarction after percutaneous coronary intervention
title_full_unstemmed Association between serum hemoglobin and major cardiovascular adverse event in Chinese patients with ST‐segment elevation myocardial infarction after percutaneous coronary intervention
title_short Association between serum hemoglobin and major cardiovascular adverse event in Chinese patients with ST‐segment elevation myocardial infarction after percutaneous coronary intervention
title_sort association between serum hemoglobin and major cardiovascular adverse event in chinese patients with st‐segment elevation myocardial infarction after percutaneous coronary intervention
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761445/
https://www.ncbi.nlm.nih.gov/pubmed/34894008
http://dx.doi.org/10.1002/jcla.24126
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