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Association between serum inflammatory parameters and the disease severity in COVID‐19 patients
OBJECTIVE: Most patients infected with the novel coronavirus (SARS‐CoV‐2), as the causative agent of COVID‐19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID‐19 patients and to investigate the correlation betwe...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761446/ https://www.ncbi.nlm.nih.gov/pubmed/34874079 http://dx.doi.org/10.1002/jcla.24162 |
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author | Mardani, Rajab namavar, Mehrnoush ghorbi, Elham Shoja, Zabihollah Zali, Fatemeh Kaghazian, Hooman Aghasadeghi, Mohammad Reza Sadeghi, Seyed Amir Sabeti, Shahram Darazam, Ilad Alavi Ahmadi, Nayebali Mousavi‐Nasab, Seyed Dawood |
author_facet | Mardani, Rajab namavar, Mehrnoush ghorbi, Elham Shoja, Zabihollah Zali, Fatemeh Kaghazian, Hooman Aghasadeghi, Mohammad Reza Sadeghi, Seyed Amir Sabeti, Shahram Darazam, Ilad Alavi Ahmadi, Nayebali Mousavi‐Nasab, Seyed Dawood |
author_sort | Mardani, Rajab |
collection | PubMed |
description | OBJECTIVE: Most patients infected with the novel coronavirus (SARS‐CoV‐2), as the causative agent of COVID‐19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID‐19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity. METHODS: In this prospective cross‐sectional study, 50 patients with COVID‐19 and 20 patients without COVID‐19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non‐severe and severe. Differences in the serum levels of C‐reactive protein (CRP), IL‐6, and TNF‐α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed. RESULTS: Out of the 50 patients with COVID‐19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID‐19 patients in terms of gender and age. Blood tests of COVID‐19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL‐6, TNF‐α, and CRP between the severe and non‐severe groups, which were higher in the severe group. Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL‐6 (r = 0.74), LYM with NEU (r = −0.97), and ESR with TNF‐α (r = 0.7). CONCLUSION: The findings of this study, as the first study in Iran, suggest that the levels of IL‐6, TNF‐α, ESR, and CRP could be used to predict the severity of COVID‐19 disease. |
format | Online Article Text |
id | pubmed-8761446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87614462022-01-20 Association between serum inflammatory parameters and the disease severity in COVID‐19 patients Mardani, Rajab namavar, Mehrnoush ghorbi, Elham Shoja, Zabihollah Zali, Fatemeh Kaghazian, Hooman Aghasadeghi, Mohammad Reza Sadeghi, Seyed Amir Sabeti, Shahram Darazam, Ilad Alavi Ahmadi, Nayebali Mousavi‐Nasab, Seyed Dawood J Clin Lab Anal Research Articles OBJECTIVE: Most patients infected with the novel coronavirus (SARS‐CoV‐2), as the causative agent of COVID‐19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID‐19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity. METHODS: In this prospective cross‐sectional study, 50 patients with COVID‐19 and 20 patients without COVID‐19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non‐severe and severe. Differences in the serum levels of C‐reactive protein (CRP), IL‐6, and TNF‐α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed. RESULTS: Out of the 50 patients with COVID‐19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID‐19 patients in terms of gender and age. Blood tests of COVID‐19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL‐6, TNF‐α, and CRP between the severe and non‐severe groups, which were higher in the severe group. Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL‐6 (r = 0.74), LYM with NEU (r = −0.97), and ESR with TNF‐α (r = 0.7). CONCLUSION: The findings of this study, as the first study in Iran, suggest that the levels of IL‐6, TNF‐α, ESR, and CRP could be used to predict the severity of COVID‐19 disease. John Wiley and Sons Inc. 2021-12-07 /pmc/articles/PMC8761446/ /pubmed/34874079 http://dx.doi.org/10.1002/jcla.24162 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Mardani, Rajab namavar, Mehrnoush ghorbi, Elham Shoja, Zabihollah Zali, Fatemeh Kaghazian, Hooman Aghasadeghi, Mohammad Reza Sadeghi, Seyed Amir Sabeti, Shahram Darazam, Ilad Alavi Ahmadi, Nayebali Mousavi‐Nasab, Seyed Dawood Association between serum inflammatory parameters and the disease severity in COVID‐19 patients |
title | Association between serum inflammatory parameters and the disease severity in COVID‐19 patients |
title_full | Association between serum inflammatory parameters and the disease severity in COVID‐19 patients |
title_fullStr | Association between serum inflammatory parameters and the disease severity in COVID‐19 patients |
title_full_unstemmed | Association between serum inflammatory parameters and the disease severity in COVID‐19 patients |
title_short | Association between serum inflammatory parameters and the disease severity in COVID‐19 patients |
title_sort | association between serum inflammatory parameters and the disease severity in covid‐19 patients |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761446/ https://www.ncbi.nlm.nih.gov/pubmed/34874079 http://dx.doi.org/10.1002/jcla.24162 |
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