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The Effects of L-Arginine in Hypertensive Patients: A Literature Review

Hypertension (HTN) is a chronic disease that affects more than 972 million people throughout the world, which is usually associated with endothelial dysfunction. Scientists are closely investigating endothelial dysfunction and have recently discovered the endothelium-derived relaxing factor (EDRF) k...

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Autores principales: Abukhodair, Abdulkarim W, Abukhudair, Walid, Alqarni, Mohammed S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761475/
https://www.ncbi.nlm.nih.gov/pubmed/35070535
http://dx.doi.org/10.7759/cureus.20485
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author Abukhodair, Abdulkarim W
Abukhudair, Walid
Alqarni, Mohammed S
author_facet Abukhodair, Abdulkarim W
Abukhudair, Walid
Alqarni, Mohammed S
author_sort Abukhodair, Abdulkarim W
collection PubMed
description Hypertension (HTN) is a chronic disease that affects more than 972 million people throughout the world, which is usually associated with endothelial dysfunction. Scientists are closely investigating endothelial dysfunction and have recently discovered the endothelium-derived relaxing factor (EDRF) known as NO (nitric oxide), which is derived from a semi-essential amino acid, L-arginine, by the action of endothelial nitric oxide synthase (eNOS). Production of adequate amounts of NO by vascular endothelial cells is essential to maintain normal blood pressure and prevent the development of HTN. Asymmetrical dimethylarginine (ADMA) is an endogenous NOS inhibitor that is increased in those with HTN especially in patients with renal dysfunction. In the present review, the role of L-arginine, arginine transporters, and ADMA in the pathobiology of HTN and their potential clinical significance are discussed.
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spelling pubmed-87614752022-01-21 The Effects of L-Arginine in Hypertensive Patients: A Literature Review Abukhodair, Abdulkarim W Abukhudair, Walid Alqarni, Mohammed S Cureus Internal Medicine Hypertension (HTN) is a chronic disease that affects more than 972 million people throughout the world, which is usually associated with endothelial dysfunction. Scientists are closely investigating endothelial dysfunction and have recently discovered the endothelium-derived relaxing factor (EDRF) known as NO (nitric oxide), which is derived from a semi-essential amino acid, L-arginine, by the action of endothelial nitric oxide synthase (eNOS). Production of adequate amounts of NO by vascular endothelial cells is essential to maintain normal blood pressure and prevent the development of HTN. Asymmetrical dimethylarginine (ADMA) is an endogenous NOS inhibitor that is increased in those with HTN especially in patients with renal dysfunction. In the present review, the role of L-arginine, arginine transporters, and ADMA in the pathobiology of HTN and their potential clinical significance are discussed. Cureus 2021-12-17 /pmc/articles/PMC8761475/ /pubmed/35070535 http://dx.doi.org/10.7759/cureus.20485 Text en Copyright © 2021, Abukhodair et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Abukhodair, Abdulkarim W
Abukhudair, Walid
Alqarni, Mohammed S
The Effects of L-Arginine in Hypertensive Patients: A Literature Review
title The Effects of L-Arginine in Hypertensive Patients: A Literature Review
title_full The Effects of L-Arginine in Hypertensive Patients: A Literature Review
title_fullStr The Effects of L-Arginine in Hypertensive Patients: A Literature Review
title_full_unstemmed The Effects of L-Arginine in Hypertensive Patients: A Literature Review
title_short The Effects of L-Arginine in Hypertensive Patients: A Literature Review
title_sort effects of l-arginine in hypertensive patients: a literature review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761475/
https://www.ncbi.nlm.nih.gov/pubmed/35070535
http://dx.doi.org/10.7759/cureus.20485
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