Key chemokines direct migration of immune cells in solid tumors

Immune cell infiltration into solid tumors, their movement within the tumor microenvironment (TME), and interaction with other immune cells are controlled by their directed migration towards gradients of chemokines. Dysregulated chemokine signaling in TME favors the growth of tumors, exclusion of ef...

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Autores principales: Kohli, Karan, Pillarisetty, Venu G., Kim, Teresa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761573/
https://www.ncbi.nlm.nih.gov/pubmed/33603130
http://dx.doi.org/10.1038/s41417-021-00303-x
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author Kohli, Karan
Pillarisetty, Venu G.
Kim, Teresa S.
author_facet Kohli, Karan
Pillarisetty, Venu G.
Kim, Teresa S.
author_sort Kohli, Karan
collection PubMed
description Immune cell infiltration into solid tumors, their movement within the tumor microenvironment (TME), and interaction with other immune cells are controlled by their directed migration towards gradients of chemokines. Dysregulated chemokine signaling in TME favors the growth of tumors, exclusion of effector immune cells, and abundance of immunosuppressive cells. Key chemokines directing the migration of immune cells into tumor tissue have been identified. In this review, we discuss well-studied chemokine receptors that regulate migration of effector and immunosuppressive immune cells in the context of cancer immunology. We discuss preclinical models that have described the role of respective chemokine receptors in immune cell migration into TME and review preclinical and clinical studies that target chemokine signaling as standalone or combination therapies.
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spelling pubmed-87615732022-01-26 Key chemokines direct migration of immune cells in solid tumors Kohli, Karan Pillarisetty, Venu G. Kim, Teresa S. Cancer Gene Ther Review Article Immune cell infiltration into solid tumors, their movement within the tumor microenvironment (TME), and interaction with other immune cells are controlled by their directed migration towards gradients of chemokines. Dysregulated chemokine signaling in TME favors the growth of tumors, exclusion of effector immune cells, and abundance of immunosuppressive cells. Key chemokines directing the migration of immune cells into tumor tissue have been identified. In this review, we discuss well-studied chemokine receptors that regulate migration of effector and immunosuppressive immune cells in the context of cancer immunology. We discuss preclinical models that have described the role of respective chemokine receptors in immune cell migration into TME and review preclinical and clinical studies that target chemokine signaling as standalone or combination therapies. Nature Publishing Group US 2021-02-18 2022 /pmc/articles/PMC8761573/ /pubmed/33603130 http://dx.doi.org/10.1038/s41417-021-00303-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Kohli, Karan
Pillarisetty, Venu G.
Kim, Teresa S.
Key chemokines direct migration of immune cells in solid tumors
title Key chemokines direct migration of immune cells in solid tumors
title_full Key chemokines direct migration of immune cells in solid tumors
title_fullStr Key chemokines direct migration of immune cells in solid tumors
title_full_unstemmed Key chemokines direct migration of immune cells in solid tumors
title_short Key chemokines direct migration of immune cells in solid tumors
title_sort key chemokines direct migration of immune cells in solid tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761573/
https://www.ncbi.nlm.nih.gov/pubmed/33603130
http://dx.doi.org/10.1038/s41417-021-00303-x
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