Cargando…

The role of the KIBRA and APOE genes in developing spatial abilities in humans

In the contemporary high-tech society, spatial abilities predict individual life and professional success, especially in the STEM (Science, Technology, Engineering, and Mathematics) disciplines. According to neurobiological hypotheses, individual differences in cognitive abilities may be attributed...

Descripción completa

Detalles Bibliográficos
Autores principales: Kazantseva, A.V., Enikeeva, R.F., Davydova, Yu.D., Mustafin, R.N., Takhirova, Z.R., Malykh, S.B., Lobaskova, M.M., Tikhomirova, T.N., Khusnutdinova, E.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761577/
https://www.ncbi.nlm.nih.gov/pubmed/35088019
http://dx.doi.org/10.18699/VJ21.097
_version_ 1784633560865439744
author Kazantseva, A.V.
Enikeeva, R.F.
Davydova, Yu.D.
Mustafin, R.N.
Takhirova, Z.R.
Malykh, S.B.
Lobaskova, M.M.
Tikhomirova, T.N.
Khusnutdinova, E.K.
author_facet Kazantseva, A.V.
Enikeeva, R.F.
Davydova, Yu.D.
Mustafin, R.N.
Takhirova, Z.R.
Malykh, S.B.
Lobaskova, M.M.
Tikhomirova, T.N.
Khusnutdinova, E.K.
author_sort Kazantseva, A.V.
collection PubMed
description In the contemporary high-tech society, spatial abilities predict individual life and professional success, especially in the STEM (Science, Technology, Engineering, and Mathematics) disciplines. According to neurobiological hypotheses, individual differences in cognitive abilities may be attributed to the functioning of genes involved in the regulation of neurogenesis and synaptic plasticity. In addition, genome-wide association studies identified rs17070145 located in the KIBRA gene, which was associated with individual differences in episodic memory. Considering a significant role of genetic and environmental components in cognitive functioning, the present study aimed to estimate the main effect of NGF (rs6330), NRXN1 (rs1045881, rs4971648), KIBRA (rs17070145), NRG1 (rs6994992), BDNF (rs6265), GRIN2B (rs3764030), APOE (rs7412, rs429358), and SNAP25 (rs363050) gene polymorphisms and to assess the effect of gene-environment interactions on individual differences in spatial ability in individuals without cognitive decline aged 18–25 years (N = 1011, 80 % women). Spatial abilities were measured using a battery of cognitive tests including the assessment of “3D shape rotation” (mental rotation). Multiple regression analysis, which was carried out in the total sample controlling for sex, ethnicity and the presence of the “risk” APOE ε4 allele, demonstrated the association of the rs17070145 Т-allele in the KIBRA gene with enhanced spatial ability (β = 1.32; pFDR = 0.037) compared to carriers of the rs17070145 CC-genotype. The analysis of gene-environment interactions revealed that nicotine smoking (β = 3.74; p = 0.010) and urban/rural residency in childhood (β = –6.94; p = 0.0002) modulated the association of KIBRA rs17070145 and АРОЕ (rs7412, rs429358) gene variants with individual differences in mental rotation, respectively. The data obtained confirm the effect of the KIBRA rs17070145 Т-allele on improved cognitive functioning and for the first time evidence the association of the mentioned genetic variant with spatial abilities in humans. A “protective” effect of the APOE ε2 allele on enhanced cognitive functioning is observed only under certain conditions related to childhood rearing.
format Online
Article
Text
id pubmed-8761577
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences
record_format MEDLINE/PubMed
spelling pubmed-87615772022-01-26 The role of the KIBRA and APOE genes in developing spatial abilities in humans Kazantseva, A.V. Enikeeva, R.F. Davydova, Yu.D. Mustafin, R.N. Takhirova, Z.R. Malykh, S.B. Lobaskova, M.M. Tikhomirova, T.N. Khusnutdinova, E.K. Vavilovskii Zhurnal Genet Selektsii Original Article In the contemporary high-tech society, spatial abilities predict individual life and professional success, especially in the STEM (Science, Technology, Engineering, and Mathematics) disciplines. According to neurobiological hypotheses, individual differences in cognitive abilities may be attributed to the functioning of genes involved in the regulation of neurogenesis and synaptic plasticity. In addition, genome-wide association studies identified rs17070145 located in the KIBRA gene, which was associated with individual differences in episodic memory. Considering a significant role of genetic and environmental components in cognitive functioning, the present study aimed to estimate the main effect of NGF (rs6330), NRXN1 (rs1045881, rs4971648), KIBRA (rs17070145), NRG1 (rs6994992), BDNF (rs6265), GRIN2B (rs3764030), APOE (rs7412, rs429358), and SNAP25 (rs363050) gene polymorphisms and to assess the effect of gene-environment interactions on individual differences in spatial ability in individuals without cognitive decline aged 18–25 years (N = 1011, 80 % women). Spatial abilities were measured using a battery of cognitive tests including the assessment of “3D shape rotation” (mental rotation). Multiple regression analysis, which was carried out in the total sample controlling for sex, ethnicity and the presence of the “risk” APOE ε4 allele, demonstrated the association of the rs17070145 Т-allele in the KIBRA gene with enhanced spatial ability (β = 1.32; pFDR = 0.037) compared to carriers of the rs17070145 CC-genotype. The analysis of gene-environment interactions revealed that nicotine smoking (β = 3.74; p = 0.010) and urban/rural residency in childhood (β = –6.94; p = 0.0002) modulated the association of KIBRA rs17070145 and АРОЕ (rs7412, rs429358) gene variants with individual differences in mental rotation, respectively. The data obtained confirm the effect of the KIBRA rs17070145 Т-allele on improved cognitive functioning and for the first time evidence the association of the mentioned genetic variant with spatial abilities in humans. A “protective” effect of the APOE ε2 allele on enhanced cognitive functioning is observed only under certain conditions related to childhood rearing. The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2021-12 /pmc/articles/PMC8761577/ /pubmed/35088019 http://dx.doi.org/10.18699/VJ21.097 Text en Copyright © AUTHORS https://creativecommons.org/licenses/by/2.5/This work is licensed under a Creative Commons Attribution 4.0 License
spellingShingle Original Article
Kazantseva, A.V.
Enikeeva, R.F.
Davydova, Yu.D.
Mustafin, R.N.
Takhirova, Z.R.
Malykh, S.B.
Lobaskova, M.M.
Tikhomirova, T.N.
Khusnutdinova, E.K.
The role of the KIBRA and APOE genes in developing spatial abilities in humans
title The role of the KIBRA and APOE genes in developing spatial abilities in humans
title_full The role of the KIBRA and APOE genes in developing spatial abilities in humans
title_fullStr The role of the KIBRA and APOE genes in developing spatial abilities in humans
title_full_unstemmed The role of the KIBRA and APOE genes in developing spatial abilities in humans
title_short The role of the KIBRA and APOE genes in developing spatial abilities in humans
title_sort role of the kibra and apoe genes in developing spatial abilities in humans
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761577/
https://www.ncbi.nlm.nih.gov/pubmed/35088019
http://dx.doi.org/10.18699/VJ21.097
work_keys_str_mv AT kazantsevaav theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT enikeevarf theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT davydovayud theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT mustafinrn theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT takhirovazr theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT malykhsb theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT lobaskovamm theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT tikhomirovatn theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT khusnutdinovaek theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT kazantsevaav roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT enikeevarf roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT davydovayud roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT mustafinrn roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT takhirovazr roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT malykhsb roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT lobaskovamm roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT tikhomirovatn roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans
AT khusnutdinovaek roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans