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Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study

Background: Habituation is considered to have protective and filtering mechanisms. The present study is aim to find the casual relationship and mechanisms of excitatory–inhibitory (E/I) dysfunctions in schizophrenia (SCZ) via habituation. Methods: A dichotic listening paradigm was performed with sim...

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Autores principales: Zheng, Leilei, Yan, Weizheng, Yu, Linzhen, Gao, Bin, Yu, Shaohua, Chen, Lili, Hao, Xiaoyi, Liu, Han, Lin, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761615/
https://www.ncbi.nlm.nih.gov/pubmed/35046846
http://dx.doi.org/10.3389/fpsyt.2021.731387
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author Zheng, Leilei
Yan, Weizheng
Yu, Linzhen
Gao, Bin
Yu, Shaohua
Chen, Lili
Hao, Xiaoyi
Liu, Han
Lin, Zheng
author_facet Zheng, Leilei
Yan, Weizheng
Yu, Linzhen
Gao, Bin
Yu, Shaohua
Chen, Lili
Hao, Xiaoyi
Liu, Han
Lin, Zheng
author_sort Zheng, Leilei
collection PubMed
description Background: Habituation is considered to have protective and filtering mechanisms. The present study is aim to find the casual relationship and mechanisms of excitatory–inhibitory (E/I) dysfunctions in schizophrenia (SCZ) via habituation. Methods: A dichotic listening paradigm was performed with simultaneous EEG recording on 22 schizophrenia patients and 22 gender- and age-matched healthy controls. Source reconstruction and dynamic causal modeling (DCM) analysis were performed to estimate the effective connectivity and casual relationship between frontal and temporal regions before and after habituation. Results: The schizophrenia patients expressed later habituation onset (p < 0.01) and hyper-activity in both lateral frontal–temporal cortices than controls (p = 0.001). The patients also showed decreased top-down and bottom-up connectivity in bilateral frontal–temporal regions (p < 0.01). The contralateral frontal–frontal and temporal–temporal connectivity showed a left to right decreasing (p < 0.01) and right to left strengthening (p < 0.01). Conclusions: The results give causal evidence for E/I imbalance in schizophrenia during dichotic auditory processing. The altered effective connectivity in frontal–temporal circuit could represent the trait bio-marker of schizophrenia with auditory hallucinations.
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spelling pubmed-87616152022-01-18 Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study Zheng, Leilei Yan, Weizheng Yu, Linzhen Gao, Bin Yu, Shaohua Chen, Lili Hao, Xiaoyi Liu, Han Lin, Zheng Front Psychiatry Psychiatry Background: Habituation is considered to have protective and filtering mechanisms. The present study is aim to find the casual relationship and mechanisms of excitatory–inhibitory (E/I) dysfunctions in schizophrenia (SCZ) via habituation. Methods: A dichotic listening paradigm was performed with simultaneous EEG recording on 22 schizophrenia patients and 22 gender- and age-matched healthy controls. Source reconstruction and dynamic causal modeling (DCM) analysis were performed to estimate the effective connectivity and casual relationship between frontal and temporal regions before and after habituation. Results: The schizophrenia patients expressed later habituation onset (p < 0.01) and hyper-activity in both lateral frontal–temporal cortices than controls (p = 0.001). The patients also showed decreased top-down and bottom-up connectivity in bilateral frontal–temporal regions (p < 0.01). The contralateral frontal–frontal and temporal–temporal connectivity showed a left to right decreasing (p < 0.01) and right to left strengthening (p < 0.01). Conclusions: The results give causal evidence for E/I imbalance in schizophrenia during dichotic auditory processing. The altered effective connectivity in frontal–temporal circuit could represent the trait bio-marker of schizophrenia with auditory hallucinations. Frontiers Media S.A. 2022-01-03 /pmc/articles/PMC8761615/ /pubmed/35046846 http://dx.doi.org/10.3389/fpsyt.2021.731387 Text en Copyright © 2022 Zheng, Yan, Yu, Gao, Yu, Chen, Hao, Liu and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Zheng, Leilei
Yan, Weizheng
Yu, Linzhen
Gao, Bin
Yu, Shaohua
Chen, Lili
Hao, Xiaoyi
Liu, Han
Lin, Zheng
Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study
title Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study
title_full Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study
title_fullStr Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study
title_full_unstemmed Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study
title_short Altered Effective Brain Connectivity During Habituation in First Episode Schizophrenia With Auditory Verbal Hallucinations: A Dichotic Listening EEG Study
title_sort altered effective brain connectivity during habituation in first episode schizophrenia with auditory verbal hallucinations: a dichotic listening eeg study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761615/
https://www.ncbi.nlm.nih.gov/pubmed/35046846
http://dx.doi.org/10.3389/fpsyt.2021.731387
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