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Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity

Characterization of I37R, a mutation located in the lasso motif of the CFTR chloride channel, was conducted by theratyping several CFTR modulators from both potentiator and corrector classes. Intestinal current measurements in rectal biopsies, forskolin-induced swelling (FIS) in intestinal organoids...

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Detalles Bibliográficos
Autores principales:	Wong, Sharon L., Awatade, Nikhil T., Astore, Miro A., Allan, Katelin M., Carnell, Michael J., Slapetova, Iveta, Chen, Po-chia, Capraro, Alexander, Fawcett, Laura K., Whan, Renee M., Griffith, Renate, Ooi, Chee Y., Kuyucak, Serdar, Jaffe, Adam, Waters, Shafagh A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761696/ https://www.ncbi.nlm.nih.gov/pubmed/35072004 http://dx.doi.org/10.1016/j.isci.2021.103710

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